{"id":61,"date":"2021-11-24T11:09:26","date_gmt":"2021-11-24T02:09:26","guid":{"rendered":"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/WordPress\/?page_id=61"},"modified":"2022-09-13T18:14:57","modified_gmt":"2022-09-13T09:14:57","slug":"research","status":"publish","type":"page","link":"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/research","title":{"rendered":"Research"},"content":{"rendered":"\n<p class=\"has-large-font-size\"><strong>\uff1a\u5742\u5009\u7814\u7a76\u5ba4\u3066\u4e3b\u306b\u53d6\u308a\u7d44\u3093\u3067\u3044\u308b\u7814\u7a76\u30c6\u30fc\u30de\u306f\u3053\u3061\u3089<\/strong><\/p>\n\n\n\n<p class=\"has-vivid-cyan-blue-color has-text-color has-large-font-size\">\u4e3b\u306a\u7814\u7a76\u30c6\u30fc\u30de<\/p>\n\n\n\n<p>\u751f\u7269\u6d3b\u6027\u7269\u8cea\u306e\u52b9\u7387\u7684\u306a\u5408\u6210\u6cd5\u306e\u958b\u767a\u3092\u76ee\u6307\u3057\u3066\uff0c\u4ee5\u4e0b\u306e\u7814\u7a76\u306b\u53d6\u308a\u7d44\u3093\u3067\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u30fb\u9178\u30fb\u5869\u57fa\u8907\u5408\u5316\u5b66\u306b\u57fa\u3065\u304f\u4e0d\u6589\u5206\u5b50\u89e6\u5a92\u306e\u7cbe\u5bc6\u8a2d\u8a08<\/p>\n\n\n\n<p>\u30fb\u7acb\u4f53\u9078\u629e\u7684\u306a\u70ad\u7d20\uff0d\u70ad\u7d20\u7d50\u5408\u5f62\u6210\u53cd\u5fdc\u306e\u958b\u767a<\/p>\n\n\n\n<p>\u30fb\u30db\u30a6\u7d20\u306e\u7279\u6027\u3092\u751f\u304b\u3057\u305f\u70ad\u7d20\u30fc\u70ad\u7d20\u7d50\u5408\u53cd\u5fdc\u306e\u958b\u767a<\/p>\n\n\n\n<p>\u30fb\u7279\u7570\u306a\u69cb\u9020\u3092\u6301\u3064\u751f\u7269\u6d3b\u6027\u7269\u8cea\u306e\u5168\u5408\u6210<\/p>\n\n\n\n<p><\/p>\n\n\n\n<p class=\"has-vivid-cyan-blue-color has-text-color has-large-font-size\">\u6700\u8fd1\u306e\u6210\u679c<\/p>\n\n\n\n<p>\uff11\uff0e\u30ad\u30e9\u30eb\u306a\u30eb\u30a4\u30b9\u9178\u89e6\u5a92\u3092\u7528\u3044\u305f\u03b1-\u30b1\u30c8\u30a8\u30b9\u30c6\u30eb\u306e\u4e0d\u6589\u7d30\u898b\uff0d\u6afb\u4e95\u53cd\u5fdc\u306e\u958b\u767a<\/p>\n\n\n\n<p style=\"font-size:14px\">\u03b1-\u30b1\u30c8\u30a8\u30b9\u30c6\u30eb\u306b\u5bfe\u3057\u3066\u70ad\u7d20\u6c42\u6838\u5264\u30921,2-\u4ed8\u52a0\u3055\u305b\u308b\u3068\uff0c\u56db\u7d1a\u03b1-\u30d2\u30c9\u30ed\u30ad\u30b7\u30ab\u30eb\u30dc\u30f3\u9178\u8a98\u5c0e\u4f53\u304c\u5f97\u3089\u308c\u307e\u3059\u3002\u672c\u7814\u7a76\u3067\u306f\uff0c\u72ec\u81ea\u306b\u958b\u767a\u3057\u305f\u30ad\u30e9\u30eb\u30eb\u30a4\u30b9\u9178\u89e6\u5a92\u3092\u7528\u3044\u308b\u3053\u3068\u306b\u3088\u308a\uff0c\u03b1-\u30b1\u30c8\u30a8\u30b9\u30c6\u30eb\u306b\u5bfe\u3059\u308b\u4e0d\u6589\u7d30\u898b\uff0d\u6afb\u4e95\u53cd\u5fdc\uff08\u30a2\u30ea\u30eb\u30b7\u30e9\u30f3\u306e1,2-\u4ed8\u52a0\u53cd\u5fdc\uff09\u3092\u958b\u767a\u3057\u307e\u3057\u305f\u3002\u3053\u308c\u307e\u3067\uff0c\u30b1\u30c8\u30f3\u306b\u5bfe\u3059\u308b\u4e0d\u6589\u7d30\u898b\uff0d\u6afb\u4e95\u53cd\u5fdc\u306f\u307b\u3068\u3093\u3069\u5831\u544a\u3055\u308c\u3066\u304a\u3089\u305a\uff0c\u03b1-\u30b1\u30c8\u30a8\u30b9\u30c6\u30eb\u306b\u5bfe\u3059\u308b\u4e0d\u6589\u53cd\u5fdc\u3068\u3057\u3066\u306f\uff0c\u672c\u7814\u7a76\u304c\u521d\u3081\u3066\u306e\u6210\u529f\u4f8b\u3067\u3059\u3002\u30e1\u30bf\u30ea\u30eb\u30b7\u30e9\u30f3\u3092\u6c42\u6838\u5264\u3068\u3057\u3066\u7528\u3044\u308b\u3068\uff0c90%\u4ee5\u4e0a\u306e\u30a8\u30ca\u30f3\u30c1\u30aa\u904e\u5270\u7387\u3067\u56db\u7d1a\u03b1-\u30d2\u30c9\u30ed\u30ad\u30b7\u30a8\u30b9\u30c6\u30eb\u304c\u751f\u6210\u3057\u307e\u3059\u3002\u5f97\u3089\u308c\u305f\u4ed8\u52a0\u751f\u6210\u7269\u306f\uff0c\u30ad\u30ca\u9178\u306e\u5408\u6210\u4e2d\u9593\u4f53\u306a\u3069\u3078\u5bb9\u6613\u306b\u5909\u63db\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u6709\u7528\u306a\u5316\u5408\u7269\u3067\u3059\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/WordPress\/wp-content\/uploads\/2021\/07\/hosomi-sakurai-about_us.png\" alt=\"\" class=\"wp-image-62\" width=\"720\" height=\"481\" srcset=\"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/WordPress\/wp-content\/uploads\/2021\/07\/hosomi-sakurai-about_us.png 960w, http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/WordPress\/wp-content\/uploads\/2021\/07\/hosomi-sakurai-about_us-300x200.png 300w, http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/WordPress\/wp-content\/uploads\/2021\/07\/hosomi-sakurai-about_us-768x513.png 768w\" sizes=\"auto, (max-width: 720px) 100vw, 720px\" \/><\/figure>\n\n\n\n<p style=\"font-size:14px\">\"Catalytic Enantioselective Hosomi\u2013Sakurai Reaction of \u03b1-Ketoesters Promoted by Chiral Copper(II) Complexes\"<br>Yutaro Niwa, Mayu Miyake, Ichiro Hayakawa, Akira Sakakura,&nbsp;<em>Chem. Commun.<\/em><strong>2019<\/strong>,&nbsp;<em>55<\/em>, 3923\u20133926.&nbsp;&nbsp;<br><a href=\"https:\/\/doi.org\/10.1039\/C9CC01159E\" target=\"_blank\" rel=\"noreferrer noopener\">DOI: 10.1039\/C9CC01159E&nbsp;<img decoding=\"async\" src=\"http:\/\/www.cc.okayama-u.ac.jp\/~sakakura\/bioorgchem\/_src\/9278\/img20180629093542651479.png\" alt=\"LinkIcon\"><\/a><\/p>\n\n\n\n<p><\/p>\n\n\n\n<p>\uff12\uff0e\u30b2\u30e9\u30cb\u30eb\u8a98\u5c0e\u4f53\u306e\u30d0\u30a4\u30aa\u30df\u30e1\u30c6\u30a3\u30c3\u30af\u306a\u30d6\u30ed\u30e2\u74b0\u5316\u53cd\u5fdc\u306b\u6709\u52b9\u306a\u89e6\u5a92\u306e\u958b\u767a<\/p>\n\n\n\n<p style=\"font-size:14px\">1-\u30d6\u30ed\u30e2-2,2-\u30b8\u30e1\u30c1\u30eb\u30b7\u30af\u30ed\u30d8\u30ad\u30b5\u30f3\u69cb\u9020\u3092\u3082\u3064\u591a\u74b0\u72b6\u30c6\u30eb\u30da\u30ce\u30a4\u30c9\u306f\uff0c\u30b2\u30e9\u30cb\u30eb\u8a98\u5c0e\u4f53\u306e\u30d6\u30ed\u30e2\u74b0\u5316\u53cd\u5fdc\u306b\u3088\u3063\u3066\u751f\u5408\u6210\u3055\u308c\u307e\u3059\u3002\u672c\u7814\u7a76\u3067\u306f\uff0c\u751f\u5408\u6210\u7d4c\u8def\u306b\u5023\u3063\u305f\u30b2\u30e9\u30cb\u30eb\u8a98\u5c0e\u4f53\u306e\u30d6\u30ed\u30e2\u74b0\u5316\u53cd\u5fdc\u3092\u4fc3\u9032\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u89e6\u5a92\u306e\u958b\u767a\u3092\u884c\u3044\uff0c\u96fb\u5b50\u6c42\u5f15\u6027\u57fa\u3092\u3082\u3064\u30c1\u30aa\u30a6\u30ec\u30a2\u304c\u512a\u308c\u305f\u89e6\u5a92\u6d3b\u6027\u3092\u793a\u3059\u3053\u3068\u3092\u898b\u51fa\u3057\u307e\u3057\u305f\u3002\u672c\u7814\u7a76\u306e\u7279\u5fb4\u306e\u4e00\u3064\u306f\uff0c\u5b89\u4fa1\u3067\u5165\u624b\u304c\u5bb9\u6613\u306a&nbsp;<em>N<\/em>-\u30d6\u30ed\u30e2\u30b3\u30cf\u30af\u9178\u30a4\u30df\u30c9\uff08NBS\uff09\u3092\u81ed\u7d20\u5316\u5264\u3068\u3057\u3066\u7528\u3044\u308b\u70b9\u3067\u3059\u3002\u307e\u305f\uff0c\u30d6\u30ed\u30e2\u74b0\u5316\u53cd\u5fdc\u306e\u53cd\u5fdc\u901f\u5ea6\u304c\uff0c\u5185\u90e8\u30a2\u30eb\u30b1\u30f3\u306e\u96fb\u5b50\u5bc6\u5ea6\u306b\u307f\u306a\u3089\u305a\uff0c\u57fa\u8cea\u672b\u7aef\u306e\u7f6e\u63db\u57fa R \u306e\u03c0\u96fb\u5b50\u5bc6\u5ea6\u306b\u3082\u4f9d\u5b58\u3059\u308b\u3053\u3068\u3092\u898b\u51fa\u3057\u307e\u3057\u305f\u3002\u3053\u306e\u65b9\u6cd5\u3092\u5229\u7528\u3057\u3066\uff0c\u542b\u81ed\u7d20\u591a\u74b0\u72b6\u30c6\u30eb\u30da\u30ce\u30a4\u30c9\u306e\u4e00\u3064\u3067\u3042\u308b4-\u30a4\u30bd\u30b7\u30e2\u30d0\u30fc\u30d0\u30c8\u30fc\u30eb\u3092\u77ed\u5de5\u7a0b\u3067\u5408\u6210\u3059\u308b\u3053\u3068\u3082\u3067\u304d\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/WordPress\/wp-content\/uploads\/2021\/07\/bromocycliation.png\" alt=\"\" class=\"wp-image-63\" width=\"720\" height=\"361\" srcset=\"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/WordPress\/wp-content\/uploads\/2021\/07\/bromocycliation.png 960w, http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/WordPress\/wp-content\/uploads\/2021\/07\/bromocycliation-300x150.png 300w, http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/WordPress\/wp-content\/uploads\/2021\/07\/bromocycliation-768x385.png 768w\" sizes=\"auto, (max-width: 720px) 100vw, 720px\" \/><\/figure>\n\n\n\n<p style=\"font-size:14px\">\"Thioureas as Highly Active Catalysts for Biomimetic Bromocyclization of Geranyl Derivatives\"<br>Miyuki Terazaki, Kei-ichi Shiomoto, Haruki Mizoguchi, Akira Sakakura,&nbsp;<em>Org. Lett.<\/em><strong>2019<\/strong>,&nbsp;<em>21<\/em>, 2073\u20132076.<br><a href=\"https:\/\/doi.org\/10.1021\/acs.orglett.9b00352\">DOI: 10.1021\/acs.orglett.9b00352&nbsp;<\/a><a href=\"https:\/\/doi.org\/10.1021\/acs.orglett.9b00352\" target=\"_blank\" rel=\"noreferrer noopener\"><img decoding=\"async\" src=\"http:\/\/www.cc.okayama-u.ac.jp\/~sakakura\/bioorgchem\/_src\/9505\/img20180629093542651479.png\" alt=\"LinkIcon\"><\/a><\/p>\n\n\n\n<p><\/p>\n\n\n\n<p>\uff13\uff0e\u7acb\u4f53\u9078\u629e\u7684\u306aHenry\u53cd\u5fdc\u3092\u5229\u7528\u3057\u305f\u30de\u30f3\u30b6\u30b7\u30b8\u30f3\u985e\u306e\u5408\u6210<\/p>\n\n\n\n<p style=\"font-size:14px\">\u3000\u30de\u30f3\u30b6\u30b7\u30b8\u30f3A\u301cC\u306f\u30d6\u30ed\u30e2\u30d4\u30ed\u30fc\u30eb\u30a2\u30eb\u30ab\u30ed\u30a4\u30c9\u306e\u4e00\u7a2e\u3067\u3042\u308a\uff0cA\u3068C\u306f\u4e92\u3044\u306b6\u4f4d\u306e\u30a2\u30df\u30ce\u57fa\u7d50\u5408\u4e0d\u6589\u56db\u7d1a\u70ad\u7d20\u306b\u95a2\u3059\u308b\u30b8\u30a2\u30b9\u30c6\u30ec\u30aa\u30de\u30fc\u3067\u3059\u3002\u307e\u305f\uff0c\u30de\u30f3\u30b6\u30b7\u30b8\u30f3B\u306f\uff0c5\u4f4d\u306b\u30d2\u30c9\u30ed\u30ad\u30b7\u57fa\u304c\u7d50\u5408\u3057\u3066\u3044\u308b\u305f\u3081\uff0c\u4e09\u9023\u7d9a\u4e0d\u6589\u70ad\u7d20\u69cb\u9020\u3092\u3082\u3061\u307e\u3059\u3002<br>\u3000\u307e\u305a\uff0c\u30de\u30f3\u30b6\u30b7\u30b8\u30f3A\u304a\u3088\u3073C\u306e\u7acb\u4f53\u9078\u629e\u7684\u306a\u5408\u6210\u6cd5\u306e\u958b\u767a\u3092\u884c\u3044\uff0c\u30ad\u30e9\u30eb\u306a\u4e8c\u7d1a\u30cb\u30c8\u30ed\u30a2\u30eb\u30ab\u30f3&nbsp;<strong>1<\/strong>&nbsp;\u3092\u5171\u901a\u539f\u6599\u3068\u3059\u308bHenry\u53cd\u5fdc\u306b\u3088\u308a\uff0c\u30de\u30f3\u30b6\u30b7\u30b8\u30f3A\u304a\u3088\u3073C\u306b\u542b\u307e\u308c\u308b\u30a2\u30df\u30ce\u57fa\u7d50\u5408\u4e0d\u6589\u56db\u7d1a\u70ad\u7d20\u3092\u7acb\u4f53\u9078\u629e\u7684\u306b\u4f5c\u308a\u5206\u3051\u308b\u65b9\u6cd5\u3092\u958b\u767a\u3057\u307e\u3057\u305f\u3002\u672c\u7814\u7a76\u306e\u7279\u5fb4\u306f\uff0c\u30ad\u30e9\u30eb\u306a\u4e8c\u7d1a\u30cb\u30c8\u30ed\u30a2\u30eb\u30ab\u30f3&nbsp;<strong>1<\/strong>\u306e\u4fdd\u8b77\u57fa\u3092\u9069\u5207\u306b\u9078\u629e\u3057\u3066Henry\u53cd\u5fdc\u306b\u304a\u3051\u308b\u53cd\u5fdc\u9077\u79fb\u72b6\u614b\u306e\u7acb\u4f53\u914d\u7f6e\u3092\u9069\u5207\u306b\u5236\u5fa1\u3059\u308b\u3053\u3068\u306b\u3088\u308a\uff0c\u30de\u30f3\u30b6\u30b7\u30b8\u30f3A\u304a\u3088\u3073C\u306b\u76f8\u5f53\u3059\u308b\u7acb\u4f53\u5316\u5b66\u3092\u4f5c\u308a\u5206\u3051\u3089\u308c\u305f\u3053\u3068\u3067\u3059\u3002\u307e\u305f\uff0c\u30de\u30f3\u30b6\u30b7\u30b8\u30f3A\u304a\u3088\u3073C\u306e\u5168\u5408\u6210\u3082\u9054\u6210\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/WordPress\/wp-content\/uploads\/2021\/07\/manzacidin.png\" alt=\"\" class=\"wp-image-64\" width=\"720\" height=\"451\" srcset=\"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/WordPress\/wp-content\/uploads\/2021\/07\/manzacidin.png 960w, http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/WordPress\/wp-content\/uploads\/2021\/07\/manzacidin-300x188.png 300w, http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/WordPress\/wp-content\/uploads\/2021\/07\/manzacidin-768x481.png 768w\" sizes=\"auto, (max-width: 720px) 100vw, 720px\" \/><\/figure>\n\n\n\n<p style=\"font-size:14px\">\"Diastereodivergent Henry Reaction for the Stereoselective Construction of Nitrogen-Containing Tetrasubstituted Carbons: Application to Total Synthesis of Manzacidins A and C\"&nbsp;<br>Takayuki Kudoh, Yuya Araki, Natsumi Miyoshi, Mizuho Tanioka, Akira Sakakura,&nbsp;<em>Asian J. Org. Chem.<\/em><strong>2017<\/strong>,&nbsp;<em>6<\/em>, 1760\u20131763. &nbsp;<br><a href=\"https:\/\/doi.org\/10.1002\/ajoc.201700568\">DOI: 10.1002\/ajoc.201700568&nbsp;<\/a><a href=\"https:\/\/doi.org\/10.1002\/ajoc.201700568\" target=\"_blank\" rel=\"noreferrer noopener\"><img decoding=\"async\" src=\"http:\/\/www.cc.okayama-u.ac.jp\/~sakakura\/bioorgchem\/_src\/9657\/img20180629093542651479.png\" alt=\"LinkIcon\"><\/a><\/p>\n\n\n\n<p style=\"font-size:14px\">\u307e\u305f\uff0c\u30de\u30f3\u30b6\u30b7\u30b8\u30f3B\u306b\u3064\u3044\u3066\u3082\u540c\u69d8\u306b\uff0c\u57fa\u8cea\u306e\u4fdd\u8b77\u57fa\u3084\u89e6\u5a92\u3068\u3057\u3066\u4f7f\u7528\u3059\u308b\u5869\u57fa\u3092\u9069\u5207\u306b\u9078\u629e\u3057\u3066Henry\u53cd\u5fdc\u3092\u30b8\u30a2\u30b9\u30c6\u30ec\u30aa\u9078\u629e\u7684\u306b\u4fc3\u9032\u3059\u308b\u3053\u3068\u306b\u3088\u308a\uff0c5\u4f4d\u304a\u3088\u30736\u4f4d\u306b\u95a2\u3059\u308b\u7acb\u4f53\u7570\u6027\u4f53\u3092\u4f5c\u308a\u5206\u3051\u308b\u3053\u3068\u306e\u3067\u304d\u308b\u5408\u6210\u6cd5\u306e\u958b\u767a\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p style=\"font-size:14px\">\"Formal Total Synthesis of Manzacidin B via Sequential Diastereodivergent Henry Reaction\"<br>Yuya Araki, Natsumi Miyoshi, Kazuki Morimoto, Takayuki Kudoh, Haruki Mizoguchi, Akira Sakakura,*&nbsp;<em>J. Org. Chem.<\/em><strong>2020<\/strong>,&nbsp;<em>85<\/em>&nbsp;(2),&nbsp;798\u2013805.<br><a href=\"https:\/\/doi.org\/10.1021\/acs.joc.9b02811\">DOI: 10.1021\/acs.joc.9b02811<\/a><a href=\"https:\/\/doi.org\/10.1021\/acs.joc.9b02811\" target=\"_blank\" rel=\"noreferrer noopener\"><img decoding=\"async\" src=\"http:\/\/www.cc.okayama-u.ac.jp\/~sakakura\/bioorgchem\/_src\/9656\/img20180629093542651479.png\" alt=\"LinkIcon\"><\/a><\/p>\n\n\n\n<p>4\uff0e\u30b7\u30af\u30ed\u30d7\u30ed\u30da\u30cb\u30eb\u30dc\u30ed\u30f3\u9178\u30a8\u30b9\u30c6\u30eb\u30a2\u30fc\u30c8\u932f\u4f53\u306e\u30e1\u30bf\u30ec\u30fc\u30c8\u8ee2\u4f4d\u53cd\u5fdc<\/p>\n\n\n\n<p style=\"font-size:14px\">\u30b7\u30af\u30ed\u30d7\u30ed\u30d1\u30f3\u5316\u5408\u7269\u306f\u533b\u85ac\u54c1\u3084\u5929\u7136\u7269\u306a\u3069\u751f\u7269\u6d3b\u6027\u5206\u5b50\u306b\u3088\u304f\u898b\u3089\u308c\u308b\u69cb\u9020\u3067\u3059\u3002\u525b\u76f4\u306a\u9aa8\u683c\u3092\u3082\u3061\u3001\u7f6e\u63db\u57fa\u306e\u4e09\u6b21\u5143\u7684\u306a\u914d\u7f6e\u3092\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3067\u304d\u308b\u305f\u3081\u3001\u591a\u304f\u306e\u7f6e\u63db\u57fa\u3084\u5b98\u80fd\u57fa\u3092\u9078\u629e\u7684\u306b\u5c0e\u5165\u3057\u305f\u30b7\u30af\u30ed\u30d7\u30ed\u30d1\u30f3\u5316\u5408\u7269\u306f\u751f\u7269\u6d3b\u6027\u5206\u5b50\u306e\u201d\u7a2e\u201d\u3068\u3057\u3066\u6709\u7528\u3067\u3042\u308b\u3068\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"has-small-font-size\">\u672c\u7814\u7a76\u3067\u306f\u3001\u30db\u30a6\u7d20\u4e0a\u306e\u7f6e\u63db\u57fa\u3092\u96a3\u306e\u70ad\u7d20\u3078\u3068\u7acb\u4f53\u7279\u7570\u7684\u306b\u8ee2\u4f4d\u3055\u305b\u308b\u3053\u3068\u304c\u3067\u304d\u308b1,2-\u30e1\u30bf\u30ec\u30fc\u30c8\u8ee2\u4f4d\u3068\u3044\u3046\u624b\u6cd5\u3092\u5229\u7528\u3057\u3066\u591a\u304f\u306e\u7f6e\u63db\u57fa\u3092\u542b\u3080\u30b7\u30af\u30ed\u30d7\u30ed\u30d4\u30eb\u30dc\u30ed\u30f3\u9178\u3092\u5408\u6210\u3057\u3088\u3046\u3068\u8003\u3048\u307e\u3057\u305f\u3002\u30b7\u30af\u30ed\u30d7\u30ed\u30da\u30cb\u30eb\u30dc\u30ed\u30f3\u9178\u30a8\u30b9\u30c6\u30eb\u30a2\u30fc\u30c8\u932f\u4f53\u3092\u57fa\u8cea\u3068\u3057\u3001\u30bb\u30ec\u30f3\u5316\u5264\u3092\u53cd\u5fdc\u306e\u30c8\u30ea\u30ac\u30fc\u3068\u3057\u3066\u7528\u3044\u308b\u3053\u3068\u3067\u3001\u03b2-\u30bb\u30ec\u30ce\u30b7\u30af\u30ed\u30d7\u30ed\u30d4\u30eb\u30dc\u30ed\u30f3\u9178\u3092\u9ad8\u7acb\u4f53\u9078\u629e\u7684\u304b\u3064\u9ad8\u53ce\u7387\u3067\u5f97\u3089\u308c\u308b\u624b\u6cd5\u3092\u958b\u767a\u3057\u307e\u3057\u305f\u3002\u30dc\u30ed\u30f3\u9178\u69cb\u9020\uff08\u70ad\u7d20\u30fc\u30db\u30a6\u7d20\u7d50\u5408\uff09\u3055\u307e\u3056\u307e\u306a\u7d50\u5408\uff08\u70ad\u7d20\u30fc\u70ad\u7d20\u3001\u70ad\u7d20\u30fc\u30d8\u30c6\u30ed\u5143\u7d20\u306a\u3069\uff09\u3078\u3068\u7acb\u4f53\u9078\u629e\u7684\u30fb\u7279\u7570\u7684\u306b\u5909\u63db\u53ef\u80fd\u306a\u6709\u7528\u306a\u4e2d\u9593\u4f53\u3067\u3042\u308b\u305f\u3081\u3001\u30d0\u30ea\u30a8\u30fc\u30b7\u30e7\u30f3\u306b\u98db\u3093\u3060\u30b7\u30af\u30ed\u30d7\u30ed\u30d1\u30f3\u5206\u5b50\u3092\u7c21\u4fbf\u306b\u4f5c\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3068\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/WordPress\/wp-content\/uploads\/2021\/07\/cyclopropene_cc_ga-1024x389.png\" alt=\"\" class=\"wp-image-101\" width=\"512\" height=\"195\" srcset=\"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/WordPress\/wp-content\/uploads\/2021\/07\/cyclopropene_cc_ga-1024x389.png 1024w, http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/WordPress\/wp-content\/uploads\/2021\/07\/cyclopropene_cc_ga-300x114.png 300w, http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/WordPress\/wp-content\/uploads\/2021\/07\/cyclopropene_cc_ga-768x292.png 768w, http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/WordPress\/wp-content\/uploads\/2021\/07\/cyclopropene_cc_ga-1536x583.png 1536w, http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/WordPress\/wp-content\/uploads\/2021\/07\/cyclopropene_cc_ga-2048x777.png 2048w\" sizes=\"auto, (max-width: 512px) 100vw, 512px\" \/><\/figure>\n\n\n\n<p class=\"has-small-font-size\">Synthesis of functionalized cyclopropylboronic esters based on a 1,2-metallate rearrangement of cyclopropenylboronate<\/p>\n\n\n\n<p class=\"has-small-font-size\">Haruki Mizoguchi,* Masaya Seriua, Akira Sakakura*\u3000<em>Chem. Commun.<\/em> <strong>2020<\/strong>, <em>56<\/em> (99), 15545\u201315548. <br><a href=\"https:\/\/pubs.rsc.org\/en\/content\/articlelanding\/2020\/cc\/d0cc07134j\" target=\"_blank\" rel=\"noreferrer noopener\">DOI: 10.1039\/d0cc07134j<\/a><\/p>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u5ca1\u5c71\u5927\u5b66\u5927\u5b66\u9662\u81ea\u7136\u79d1\u5b66\u7814\u7a76\u79d1\u3000\u751f\u7269\u6709\u6a5f\u5316\u5b66\u7814\u7a76\u5ba4\uff08\u5742\u5009\u7814\u7a76\u5ba4\uff09\u306eHP\u3067\u3059\u3002\u5f53\u7814\u7a76\u5ba4\u3067\u306f\u3001\u5929\u7136\u6709\u6a5f\u5316\u5408\u7269\u306b\u5b66\u3073\u306a\u304c\u3089\u3001\u7acb\u4f53\u9078\u629e\u7684\u306a\u53cd\u5fdc\u3092\u53ef\u80fd\u3068\u3059\u308b\u30eb\u30a4\u30b9\u9178\u89e6\u5a92\u3084\u6709\u6a5f\u5206\u5b50\u89e6\u5a92\u306e\u958b\u767a\u30db\u30a6\u7d20\u306e\u7279\u6027\u3092\u751f\u304b\u3057\u305f\u53cd\u5fdc\u958b\u767a\u751f\u7269\u6d3b\u6027\u5206\u5b50\u306e\u5408\u6210\u306a\u3069\u306b\u53d6\u308a\u7d44\u3093\u3067\u3044\u307e\u3059\uff01\uff01<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"vkexunit_cta_each_option":"","footnotes":""},"class_list":["post-61","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/wp-json\/wp\/v2\/pages\/61","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/wp-json\/wp\/v2\/comments?post=61"}],"version-history":[{"count":9,"href":"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/wp-json\/wp\/v2\/pages\/61\/revisions"}],"predecessor-version":[{"id":372,"href":"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/wp-json\/wp\/v2\/pages\/61\/revisions\/372"}],"wp:attachment":[{"href":"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/wp-json\/wp\/v2\/media?parent=61"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}