{"id":103,"date":"2021-11-25T15:46:48","date_gmt":"2021-11-25T06:46:48","guid":{"rendered":"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/WordPress\/?p=103"},"modified":"2021-11-25T15:59:33","modified_gmt":"2021-11-25T06:59:33","slug":"kinetic-resolution-of-%ce%b1-nitrolactones-by-catalytic-asymmetric-hydrolysis-or-ester-amide-exchange-reaction","status":"publish","type":"post","link":"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/archives\/103","title":{"rendered":"Kinetic Resolution of \u03b1-Nitrolactones by Catalytic Asymmetric Hydrolysis or Ester\u2013Amide Exchange Reaction"},"content":{"rendered":"\n<p>Ryota Nakao, Yudai Fujii, Ichiro Hayakawa, Haruki Mizoguchi, Akira Sakakura*&nbsp;<br><em>Synlett<\/em><strong>2020<\/strong>,&nbsp;<em>31<\/em>&nbsp;(20), 2018\u20132022. (Published online: October 8, 2020)&nbsp;<br><a href=\"https:\/\/doi.org\/10.1055\/s-0040-1707303\">DOI: 10.1055\/s-0040-1707303&nbsp;<img decoding=\"async\" src=\"http:\/\/www.cc.okayama-u.ac.jp\/~sakakura\/bioorgchem\/_src\/10593\/img20180629093542651479.png\" alt=\"LinkIcon\"><\/a><\/p>\n\n\n\n<figure class=\"wp-block-image size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/WordPress\/wp-content\/uploads\/2021\/07\/nitrocoumarin-kr-1024x446.png\" alt=\"\" class=\"wp-image-104\" width=\"512\" height=\"223\" srcset=\"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/WordPress\/wp-content\/uploads\/2021\/07\/nitrocoumarin-kr-1024x446.png 1024w, http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/WordPress\/wp-content\/uploads\/2021\/07\/nitrocoumarin-kr-300x131.png 300w, http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/WordPress\/wp-content\/uploads\/2021\/07\/nitrocoumarin-kr-768x335.png 768w, http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/WordPress\/wp-content\/uploads\/2021\/07\/nitrocoumarin-kr-1536x670.png 1536w, http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/WordPress\/wp-content\/uploads\/2021\/07\/nitrocoumarin-kr.png 1679w\" sizes=\"auto, (max-width: 512px) 100vw, 512px\" \/><\/figure>\n\n\n\n<p><em>C<\/em>1-Symmetric chiral ammonium salt catalysts induced a kinetic resolution of racemic \u03b1-nitrolactones through an asymmetric ester\u2013amide exchange reaction.&nbsp; The corresponding amides were obtained with high enantioselectivities and high&nbsp;<em>S<\/em>&nbsp;(=&nbsp;<em>k<\/em>fast\/&nbsp;<em>k<\/em>slow) values.&nbsp; This reaction system is a useful approach for obtaining carbocyclic quaternary \u03b1-nitroamides as chiral building blocks.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Ryota Nakao, Yudai Fujii, Ichiro Hayakawa, Haruki Mizoguchi, Akira Sakakura*&nbsp;Synlett2020,&nbsp;31&nbsp;(2 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":104,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"vkexunit_cta_each_option":"","footnotes":""},"categories":[6],"tags":[],"class_list":["post-103","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-publications"],"_links":{"self":[{"href":"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/wp-json\/wp\/v2\/posts\/103","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/wp-json\/wp\/v2\/comments?post=103"}],"version-history":[{"count":2,"href":"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/wp-json\/wp\/v2\/posts\/103\/revisions"}],"predecessor-version":[{"id":267,"href":"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/wp-json\/wp\/v2\/posts\/103\/revisions\/267"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/wp-json\/wp\/v2\/media\/104"}],"wp:attachment":[{"href":"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/wp-json\/wp\/v2\/media?parent=103"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/wp-json\/wp\/v2\/categories?post=103"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/wp-json\/wp\/v2\/tags?post=103"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}