{"id":129,"date":"2021-11-25T15:45:29","date_gmt":"2021-11-25T06:45:29","guid":{"rendered":"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/WordPress\/?p=129"},"modified":"2021-11-25T15:57:04","modified_gmt":"2021-11-25T06:57:04","slug":"catalytic-enantioselective-hosomi-sakurai-reaction-of-%ce%b1-ketoesters-promoted-by-chiral-copperii-complexes","status":"publish","type":"post","link":"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/archives\/129","title":{"rendered":"Catalytic Enantioselective Hosomi\u2013Sakurai Reaction of \u03b1-Ketoesters Promoted by Chiral Copper(II) Complexes"},"content":{"rendered":"\n<p>Yutaro Niwa, Mayu Miyake, Ichiro Hayakawa, Akira Sakakura*&nbsp;<br><em>Chem. Commun.<\/em><strong>2019<\/strong>,&nbsp;<em>55<\/em>&nbsp;(27), 3923\u20133926.&nbsp; (Published online: March&nbsp;&nbsp;5, 2019)&nbsp;<br><a href=\"https:\/\/doi.org\/10.1039\/C9CC01159E\">DOI: 10.1039\/C9CC01159E&nbsp;<img decoding=\"async\" src=\"http:\/\/www.cc.okayama-u.ac.jp\/~sakakura\/bioorgchem\/_src\/9495\/img20180629093542651479.png\" alt=\"LinkIcon\"><\/a><\/p>\n\n\n\n<figure class=\"wp-block-image size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/WordPress\/wp-content\/uploads\/2021\/07\/12-addition-1024x519.png\" alt=\"\" class=\"wp-image-130\" width=\"512\" height=\"260\" srcset=\"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/WordPress\/wp-content\/uploads\/2021\/07\/12-addition-1024x519.png 1024w, http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/WordPress\/wp-content\/uploads\/2021\/07\/12-addition-300x152.png 300w, http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/WordPress\/wp-content\/uploads\/2021\/07\/12-addition-768x389.png 768w, http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/WordPress\/wp-content\/uploads\/2021\/07\/12-addition-1536x778.png 1536w, http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/WordPress\/wp-content\/uploads\/2021\/07\/12-addition.png 1923w\" sizes=\"auto, (max-width: 512px) 100vw, 512px\" \/><\/figure>\n\n\n\n<p>A catalytic enantioselective Hosomi\u2013Sakurai reaction of \u03b1-ketoesters has been developed.&nbsp; A copper(II) complex with a chiral bis(oxazoline) ligand bearing methanesulfonamide groups shows excellent catalytic activity to give \u03b1,\u03b1-disubstituted \u03b1-hydroxyesters in high yields with high enantioselectivities.&nbsp; This is the first successful method for the catalytic enantioselective 1,2-addition of \u03b1-ketoesters with allylic silanes.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Yutaro Niwa, Mayu Miyake, Ichiro Hayakawa, Akira Sakakura*&nbsp;Chem. Commun.2019,&nbsp;55&nbsp;(27), 3923\u2013392 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":130,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"vkexunit_cta_each_option":"","footnotes":""},"categories":[6],"tags":[],"class_list":["post-129","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-publications"],"_links":{"self":[{"href":"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/wp-json\/wp\/v2\/posts\/129","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/wp-json\/wp\/v2\/comments?post=129"}],"version-history":[{"count":2,"href":"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/wp-json\/wp\/v2\/posts\/129\/revisions"}],"predecessor-version":[{"id":260,"href":"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/wp-json\/wp\/v2\/posts\/129\/revisions\/260"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/wp-json\/wp\/v2\/media\/130"}],"wp:attachment":[{"href":"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/wp-json\/wp\/v2\/media?parent=129"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/wp-json\/wp\/v2\/categories?post=129"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/wp-json\/wp\/v2\/tags?post=129"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}