{"id":132,"date":"2021-11-25T15:45:12","date_gmt":"2021-11-25T06:45:12","guid":{"rendered":"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/WordPress\/?p=132"},"modified":"2021-11-25T15:56:28","modified_gmt":"2021-11-25T06:56:28","slug":"chiral-pyrophosphoric-acid-catalysts-for-the-para-selective-and-eanantioselective-aza-friedel-crafts-reaction-of-phenols","status":"publish","type":"post","link":"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/archives\/132","title":{"rendered":"Chiral Pyrophosphoric Acid Catalysts for the para-Selective and Eanantioselective Aza-Friedel\u2013Crafts Reaction of Phenols"},"content":{"rendered":"\n<p>Haruka Okamoto, Kohei Toh, Takuya Mochizuki, Hidefumi Nakatsuji, Akira Sakakura,* Manabu Hatano,* Kazuaki Ishihara*&nbsp;<br><em>Synthesis<\/em><strong>2018<\/strong>,&nbsp;<em>50<\/em>&nbsp;(23), 4577\u20134590.&nbsp; (Published online: Aug&nbsp;&nbsp;22, 2018)&nbsp;<br><a href=\"https:\/\/doi.org\/10.1055\/s-0037-1610250\">DOI: 10.1055\/s-0037-1610250&nbsp;<img decoding=\"async\" src=\"http:\/\/www.cc.okayama-u.ac.jp\/~sakakura\/bioorgchem\/_src\/9488\/img20180629093542651479.png\" alt=\"LinkIcon\"><\/a><\/p>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/WordPress\/wp-content\/uploads\/2021\/07\/pyrophosphoric_acid_catalysts.png\" alt=\"\" class=\"wp-image-133\" width=\"420\" height=\"198\" srcset=\"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/WordPress\/wp-content\/uploads\/2021\/07\/pyrophosphoric_acid_catalysts.png 560w, http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/WordPress\/wp-content\/uploads\/2021\/07\/pyrophosphoric_acid_catalysts-300x141.png 300w\" sizes=\"auto, (max-width: 420px) 100vw, 420px\" \/><\/figure>\n\n\n\n<p>Chiral BINOL-derived pyrophosphoric acid catalysts were developed and used for the regio- and enantioselective aza-Friedel\u2013Crafts reaction of phenols with aldimines.&nbsp;&nbsp;<em>ortho<\/em>\/&nbsp;<em>para<\/em>-Directing phenols could react at the para-position selectively with moderate to good enantioselectivities.&nbsp; Moreover, the gram-scale transformation of a product into the key intermediate for the antifungal agent (&nbsp;<em>R<\/em>)-bifonazole was demonstrated.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Haruka Okamoto, Kohei Toh, Takuya Mochizuki, Hidefumi Nakatsuji, Akira Sakakura,* Manabu Hatano,* Kazuaki Ishi [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":133,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"vkexunit_cta_each_option":"","footnotes":""},"categories":[6],"tags":[],"class_list":["post-132","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-publications"],"_links":{"self":[{"href":"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/wp-json\/wp\/v2\/posts\/132","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/wp-json\/wp\/v2\/comments?post=132"}],"version-history":[{"count":2,"href":"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/wp-json\/wp\/v2\/posts\/132\/revisions"}],"predecessor-version":[{"id":259,"href":"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/wp-json\/wp\/v2\/posts\/132\/revisions\/259"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/wp-json\/wp\/v2\/media\/133"}],"wp:attachment":[{"href":"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/wp-json\/wp\/v2\/media?parent=132"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/wp-json\/wp\/v2\/categories?post=132"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/wp-json\/wp\/v2\/tags?post=132"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}