{"id":181,"date":"2021-11-25T15:42:32","date_gmt":"2021-11-25T06:42:32","guid":{"rendered":"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/WordPress\/?p=181"},"modified":"2021-11-25T15:51:13","modified_gmt":"2021-11-25T06:51:13","slug":"phosphite-urea-cooperative-high-turnover-catalysts-for-the-highly-selective-bromocyclization-of-homogeranylarenes","status":"publish","type":"post","link":"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/archives\/181","title":{"rendered":"\u201cPhosphite\u2013Urea\u201d Cooperative High-Turnover Catalysts for the Highly Selective Bromocyclization of Homogeranylarenes"},"content":{"rendered":"\n<p>Yasuhiro Sawamura, Hidefumi Nakatsuji, Akira Sakakura* and Kazuaki Ishihara*&nbsp;<br><em>Chem. Sci.<\/em><strong>2013<\/strong>,&nbsp;<em>4<\/em>&nbsp;(11), 4181\u20134186. &nbsp;(Published online: 02 Aug 2013)&nbsp;<br><a href=\"https:\/\/doi.org\/10.1039\/c3sc51432c\">DOI: 10.1039\/C3SC51432C&nbsp;<img decoding=\"async\" src=\"http:\/\/www.cc.okayama-u.ac.jp\/~sakakura\/bioorgchem\/_src\/9153\/img20180629093542651479.png\" alt=\"LinkIcon\"><\/a><\/p>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/WordPress\/wp-content\/uploads\/2021\/08\/bromocycl_chemsci.png\" alt=\"\" class=\"wp-image-182\" width=\"480\" height=\"249\" srcset=\"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/WordPress\/wp-content\/uploads\/2021\/08\/bromocycl_chemsci.png 960w, http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/WordPress\/wp-content\/uploads\/2021\/08\/bromocycl_chemsci-300x156.png 300w, http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/WordPress\/wp-content\/uploads\/2021\/08\/bromocycl_chemsci-768x398.png 768w\" sizes=\"auto, (max-width: 480px) 100vw, 480px\" \/><\/figure>\n\n\n\n<p>Nucleophilic phosphite-urea cooperative high-turnover catalysts have been designed for the highly selective bromocyclization of homogeranylarenes. &nbsp;The introduction of a urea moiety and bulky aryl groups in the catalyst inhibits decomposition of the catalyst and the generation of byproducts. &nbsp;Only 0.5 mol% of the catalyst successfully promotes the bromocyclization of 4-homogeranyltoluene to give the desired product in 96% yield.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Yasuhiro Sawamura, Hidefumi Nakatsuji, Akira Sakakura* and Kazuaki Ishihara*&nbsp;Chem. Sci.2013,&nbsp;4&nbsp; [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":182,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"vkexunit_cta_each_option":"","footnotes":""},"categories":[6],"tags":[],"class_list":["post-181","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-publications"],"_links":{"self":[{"href":"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/wp-json\/wp\/v2\/posts\/181","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/wp-json\/wp\/v2\/comments?post=181"}],"version-history":[{"count":2,"href":"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/wp-json\/wp\/v2\/posts\/181\/revisions"}],"predecessor-version":[{"id":244,"href":"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/wp-json\/wp\/v2\/posts\/181\/revisions\/244"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/wp-json\/wp\/v2\/media\/182"}],"wp:attachment":[{"href":"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/wp-json\/wp\/v2\/media?parent=181"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/wp-json\/wp\/v2\/categories?post=181"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/wp-json\/wp\/v2\/tags?post=181"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}