{"id":184,"date":"2021-11-25T15:42:18","date_gmt":"2021-11-25T06:42:18","guid":{"rendered":"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/WordPress\/?p=184"},"modified":"2021-11-25T15:50:52","modified_gmt":"2021-11-25T06:50:52","slug":"enantioselective-cyanoethoxycarbonylation-of-isatins-promoted-by-a-lewis-base-bronsted-acid-cooperative-catalyst","status":"publish","type":"post","link":"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/archives\/184","title":{"rendered":"Enantioselective Cyanoethoxycarbonylation of Isatins Promoted by a Lewis Base\u2013Br\u00f8nsted Acid Cooperative Catalyst"},"content":{"rendered":"\n<p>Yoshihiro Ogura, Matsujiro Akakura, Akira Sakakura,* Kazuaki Ishihara*&nbsp;<br><em>Angew. Chem. Int. Ed.<\/em><strong>2013<\/strong>,&nbsp;<em>52<\/em>&nbsp;(32), 8299\u20138303.&nbsp;&nbsp;(Published online:&nbsp;03 July 2013)&nbsp;<br><a href=\"https:\/\/doi.org\/10.1002\/anie.201303572\">DOI: 10.1002\/anie.201303572&nbsp;<img decoding=\"async\" src=\"http:\/\/www.cc.okayama-u.ac.jp\/~sakakura\/bioorgchem\/_src\/9154\/img20180629093542651479.png\" alt=\"LinkIcon\"><\/a><\/p>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/WordPress\/wp-content\/uploads\/2021\/08\/cyanocarbonylation.png\" alt=\"\" class=\"wp-image-185\" width=\"480\" height=\"231\" srcset=\"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/WordPress\/wp-content\/uploads\/2021\/08\/cyanocarbonylation.png 960w, http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/WordPress\/wp-content\/uploads\/2021\/08\/cyanocarbonylation-300x144.png 300w, http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/WordPress\/wp-content\/uploads\/2021\/08\/cyanocarbonylation-768x370.png 768w\" sizes=\"auto, (max-width: 480px) 100vw, 480px\" \/><\/figure>\n\n\n\n<p><strong>Teaming up to make it happen:<\/strong>&nbsp;In the title reaction, the Lewis basic site of the catalyst activated ethyl cyanoformate, and the deep and flexible Br\u00f8nsted acidic cavity stabilized and selectively recognized the key reaction intermediate to promote asymmetric acylation (see scheme).<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Yoshihiro Ogura, Matsujiro Akakura, Akira Sakakura,* Kazuaki Ishihara*&nbsp;Angew. Chem. Int. Ed.2013,&nbsp;52 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":185,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"vkexunit_cta_each_option":"","footnotes":""},"categories":[6],"tags":[],"class_list":["post-184","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-publications"],"_links":{"self":[{"href":"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/wp-json\/wp\/v2\/posts\/184","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/wp-json\/wp\/v2\/comments?post=184"}],"version-history":[{"count":2,"href":"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/wp-json\/wp\/v2\/posts\/184\/revisions"}],"predecessor-version":[{"id":243,"href":"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/wp-json\/wp\/v2\/posts\/184\/revisions\/243"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/wp-json\/wp\/v2\/media\/185"}],"wp:attachment":[{"href":"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/wp-json\/wp\/v2\/media?parent=184"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/wp-json\/wp\/v2\/categories?post=184"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/wp-json\/wp\/v2\/tags?post=184"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}