{"id":187,"date":"2021-11-25T15:31:07","date_gmt":"2021-11-25T06:31:07","guid":{"rendered":"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/WordPress\/?p=187"},"modified":"2021-11-25T15:50:29","modified_gmt":"2021-11-25T06:50:29","slug":"primary-alkylboronic-acids-as-highly-active-catalysts-for-the-dehydrative-amide-condensation-of-%ce%b1-hydroxycarboxylic-acids","status":"publish","type":"post","link":"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/archives\/187","title":{"rendered":"Primary Alkylboronic Acids as Highly Active Catalysts for the Dehydrative Amide Condensation of \u03b1-Hydroxycarboxylic Acids"},"content":{"rendered":"\n<p>Risa Yamashita, Akira Sakakura,* Kazuaki Ishihara*&nbsp;<br><em>Org. Lett.<\/em><strong>2013<\/strong>,&nbsp;<em>15<\/em>&nbsp;(14), 3654\u20133657. &nbsp;(Published online: 26&nbsp;June&nbsp;&nbsp;2013)&nbsp;<br><a href=\"https:\/\/doi.org\/10.1021\/ol401537f\">DOI: 10.1021\/ol401537f&nbsp;<img decoding=\"async\" src=\"http:\/\/www.cc.okayama-u.ac.jp\/~sakakura\/bioorgchem\/_src\/9155\/img20180629093542651479.png\" alt=\"LinkIcon\"><\/a><\/p>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/WordPress\/wp-content\/uploads\/2021\/08\/amidation_ol.png\" alt=\"\" class=\"wp-image-188\" width=\"480\" height=\"130\" srcset=\"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/WordPress\/wp-content\/uploads\/2021\/08\/amidation_ol.png 960w, http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/WordPress\/wp-content\/uploads\/2021\/08\/amidation_ol-300x81.png 300w, http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/WordPress\/wp-content\/uploads\/2021\/08\/amidation_ol-768x207.png 768w\" sizes=\"auto, (max-width: 480px) 100vw, 480px\" \/><\/figure>\n\n\n\n<p>Primary alkylboronic acids such as methylboronic acid and butylboronic acid are highly active catalysts for the dehydrative amide condensation of \u03b1-hydroxycarboxylic acids. &nbsp;The catalytic activities of these primary alkylboronic acids are much higher than those of the previously reported arylboronic acids. &nbsp;The present method was easily applied to a large-scale synthesis, and 14 g of an amide was obtained in a single reaction.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Risa Yamashita, Akira Sakakura,* Kazuaki Ishihara*&nbsp;Org. Lett.2013,&nbsp;15&nbsp;(14), 3654\u20133657. &nbsp;(P [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":188,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"vkexunit_cta_each_option":"","footnotes":""},"categories":[6],"tags":[],"class_list":["post-187","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-publications"],"_links":{"self":[{"href":"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/wp-json\/wp\/v2\/posts\/187","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/wp-json\/wp\/v2\/comments?post=187"}],"version-history":[{"count":2,"href":"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/wp-json\/wp\/v2\/posts\/187\/revisions"}],"predecessor-version":[{"id":239,"href":"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/wp-json\/wp\/v2\/posts\/187\/revisions\/239"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/wp-json\/wp\/v2\/media\/188"}],"wp:attachment":[{"href":"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/wp-json\/wp\/v2\/media?parent=187"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/wp-json\/wp\/v2\/categories?post=187"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/wp-json\/wp\/v2\/tags?post=187"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}