{"id":406,"date":"2023-07-11T17:03:09","date_gmt":"2023-07-11T08:03:09","guid":{"rendered":"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/?p=406"},"modified":"2025-06-13T11:02:05","modified_gmt":"2025-06-13T02:02:05","slug":"visible-light-photoexcited-palladium-catalyzed-silylmethylation-of-benzyl-alcohol-derivatives","status":"publish","type":"post","link":"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/archives\/406","title":{"rendered":"Visible-Light-Photoexcited Palladium-Catalyzed Silylmethylation of Benzyl Alcohol Derivatives"},"content":{"rendered":"\n<p class=\"has-small-font-size\">Haruki Mizoguchi*,Ryuji Yoshida,&nbsp;Haruka Ikeda, Akira Sakakura*<br><em>Synlett<\/em>&nbsp;<strong>2023<\/strong>,&nbsp;<em>eFirst (Special Issue Dedicated to Prof. Hisashi Yamamoto)<\/em><br>DOI: 10.1055\/s-0042-1752736<\/p>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/WordPress\/wp-content\/uploads\/2023\/07\/i_u0181_ga_10-1055_s-0042-1752736.gif\" alt=\"\" class=\"wp-image-404\" width=\"592\" height=\"197\"\/><\/figure>\n\n\n\n<p>An intramolecular C\u2013H silylmethylation of benzylic alcohol derivatives catalyzed by a visible-light-photoexcited palladium complex was developed. Irradiation of the palladium complex with blue LEDs resulted in efficient activation of a C\u2013I bond, and subsequent intramolecular radical arylation afforded siloxacycle products. Selective protonation or oxidation of the C\u2013Si bond of the cyclized materials afforded&nbsp;<em>ortho<\/em>-methylated and&nbsp;<em>ortho<\/em>-hydroxymethylated derivatives of the benzylic alcohol derivatives.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Haruki Mizoguchi*,Ryuji Yoshida,&nbsp;Haruka Ikeda, Akira Sakakura*Synlett&nbsp;2023,&nbsp;eFirst (Special Iss [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":404,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"vkexunit_cta_each_option":"","footnotes":""},"categories":[4,6],"tags":[],"class_list":["post-406","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","category-publications"],"_links":{"self":[{"href":"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/wp-json\/wp\/v2\/posts\/406","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/wp-json\/wp\/v2\/comments?post=406"}],"version-history":[{"count":1,"href":"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/wp-json\/wp\/v2\/posts\/406\/revisions"}],"predecessor-version":[{"id":407,"href":"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/wp-json\/wp\/v2\/posts\/406\/revisions\/407"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/wp-json\/wp\/v2\/media\/404"}],"wp:attachment":[{"href":"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/wp-json\/wp\/v2\/media?parent=406"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/wp-json\/wp\/v2\/categories?post=406"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/achem.okayama-u.ac.jp\/bioorgchem\/wp-json\/wp\/v2\/tags?post=406"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}