A Facile Access to 3-Allyl- and 3-Benzyl-3-cephems via Reductive Addition/Cyclization of Allenecarboxylate with Allyl and Benzyl Halides in an Al/Pb/Ni Redox System

Tanaka, H.; Sumida, S.-i.; Sorajo, K.; Torii, S. J. Chem. Soc., Chem. Commun. 1994, 1461.

A seuqential reductive addition/cyclization reaction of allenecarboxylate, derived from penicillin G, with allyl; and benzyl halides was successfully performed by the aid of aluminium metal and catalytic amounts of PbBr₂ and NiCl₂(bpy) to afford 3-allyl- and 3-benzyl-3-cephems, respectively.