A Novel Approach to 6-Substituted 4-Pyridone-3-carboxylic Esters by Palladium-Catalyzed Carbonylative Coupling

Torii, S.; Xu, L. H.; Okumoto, H. Synlett 1991, 695.

A facile synthesis of the antibacterials, 6-substituted methyl 4-pyridone-3-carboxylates 4, has been accomplished through palladium-catalyzed carbonylative coupling of 2-bromo-3- aminoacrylates 1 with terminal acethylenes 2 followed by cyclization.