Electroreduction of 5-Chloro-7-nitrobenzofuran Derivative. A Facile Access to A key Intermediate for ACAT Inhibibors

Torii, S.; Okumoto, H.; Minoshima, T.; Kurozumi, S. Synlett 1994, 68.

Electroreduction of 5-chloro-7-nitro-2,2,4,6-tetramethyl-2,3-dihudrobenz[b]furan in a DMF-tBuOH/Bu₄NBF₄/Zn-Zn system effected conversion of the nitro group into amine and ensuing removal of the chlorine atom in one pot, leading to a pivotal precursor for ACAT inhibitors.