Deprotection of Carboxylic Esters Assisted by Hydrogen Bonding Network in Phenolic Media. Its Application tob-Lactam Antibiotic Syntheses

Tanaka, H.; Taniguchi, M.; Kameyama, Y.; Torii, S.; Sasaoka, M.; Shiroi, T.; Kikuchi, R.; Kawahara, I.; Shimabayashi, A.; Nagao, S. Tetrahedron Lett. 1990, 31. 6661.

Deprotection of p-methoxybenzyl, diphenylmethyl, and tert-butyl ester groups, which is an essential step of b-lactam antibiotic synthesis, can be performed successfully by gentle heating in phenolic media.