Asymmertric Multipoint Control by Palladium-Catalyzed Diastereoselective Tandem Carbon-Carbon Bond Formation

Torii, S.; Okumoto, H.; Kotani, T.; Nakayasu, S.; Ozaki, H. Tetrahedron Lett. 1992, 33, 3503.

Palladium-catalyzed diastereo-differentiative tandem connection of cis-alkenyl iodide, cyclic fragment, and terminal acetylene was executed. The discrimination of the diastereotopic face and olefinic carbons of norbornene was achieved with accompanying isomerization of the cis-geometry of the olefin to trans in good yields.