論 文 発 表  


[2017

Synthetically Useful Variants of Industrial Lipases from Burkholderia cepacia and Pseudomonas fluorescens.
Org. Biomol. Chem. 2017, 15, in press.
Yoshida, K.; Ono, M.; Yamamoto, T.; Utsumi, T.; Koikeda, S.; Ema, T.

Carbazole-Based BODIPYs with Ethynyl Substituents at the Boron Center: Solid-State Excimer Fluorescence in the VIS/NIR Region.
Org. Biomol. Chem. 2017, 15, in press.
Maeda, C.; Nagahata, K.; Ema, T.

Chiral Macrocyclic Organocatalysts for Kinetic Resolution of Disubstituted Epoxides with Carbon Dioxide.
Org. Lett. 2017, 19, 4070-4073.
Ema, T.; Yokoyama, M.; Watanabe, S.; Sasaki, S.; Ota, H.; Takaishi, K.

Spectroscopic Discrimination of Diastereomeric Complexes Involving an Axially Chiral Receptor.
ChemPhysChem 2017, 18, 2475-2481.
Filippi, A.; Fraschetti, C.; Guarcini, L.; Zazza, C.; Ema, T.; Speranza, M.

Helical Oligonaphthodioxepins Showing Intense CPL in Solution and in the Solid State.
Chem. Eur. J. 2017, 23, 9249-9252.
Takaishi, K.; Yamamoto, T.; Hinoide, S.; Ema, T.
< Hot Paper >

Electronic Tuning of Zinc Porphyrin Catalysts for the Conversion of Epoxides and CO2 into Cyclic Carbonates.
ChemCatChem 2017, 9, 946-949.
Maeda, C.; Sasaki, S.; Ema, T.


Magnetic Attachment of Lipase Immobilized on Bacteriogenic Iron Oxide Inside a Microtube Reactor for the Kinetic Resolution of Secondary Alcohols.
Synlett 2017, 28, 805-810.
Mandai, K.; Fukuda, T.; Miyazaki, Y.; Hashimoto, H.; Mandai, H.; Ema, T.; Takada, J.; Suga, S.


[2016

Intramolecular Electronic Coupling in the Thiophene-Bridged Carbazole-Based Diporphyrin.
Org. Lett. 2016, 18, 6070-6073.
Maeda, C.; Takata, M.; Honsho, A.; Ema, T.
< Synfacts >


Solvent-Free Benzoin and Stetter Reactions with a Small Amount of NHC Catalyst in the Liquid or Semisolid State.
Org. Lett. 2016, 18, 5764-5767.
Ema, T.; Nanjo, Y.; Shiratori, S.; Terao, Y.; Kimura, R.


Color-Tunable Solid-State Fluorescence from Carbazole-Based BODIPYs.
Chem. Eur. J. 2016, 22, 7508-7513.
Maeda, C.; Todaka, T.; Ueda, T.; Ema, T.


Highly Active and Robust Metalloporphyrin Catalysts for the Synthesis of Cyclic Carbonates from a Broad Range of Epoxides and Carbon Dioxide.
Chem. Eur. J. 2016, 22, 6556-6563.
Maeda, C.; Shimonishi, J.; Miyazaki, R.; Hasegawa, J.; Ema, T.
< Hot Paper >
< Frontispiece >


Determination of Enantiomeric Excess of Carboxylates by Fluorescent Macrocyclic Sensors.
Chem. Sci. 2016, 7, 2016-2022.
Akdeniz, A.; Minami, T.; Watanabe, S.; Yokoyama, M.; Ema, T.; Anzenbacher, P., Jr.


Theoretical Study on Highly Active Bifunctional Metalloporphyrin Catalysts for the Coupling Reaction of Epoxides with Carbon Dioxide.
Chem. Rec. 2016, 16, 2260-2267.
Hasegawa, J.; Miyazaki, R.; Maeda, C.; Ema, T.
< Account >

Double Mutant Lipase with Enhanced Activity and Enantioselectivity for Bulky Secondary Alcohols.
Ema, T.; Kamata, S.; Nakano, Y.; Yoshida, D.; Sakai, T. (contributed authors) In Practical Methods for Biocatalysis and Biotransformations 3; Whittall, J., Sutton, P., Kroutil, W., Eds.; Wiley: West Sussex, 2016.


CO2固定化のための二官能性分子触媒:相乗効果を高める構造最適化
有機合成化学協会誌, 2016, 74, 814-823.
前田千尋, 依馬 正


[2015

Chemical Modification of Lipase for Rational Enhancement of Enantioselectivity.
Chem. Lett. 2015, 44, 1374-1376.
Ema, T.; Inoue, H.
< Editor's Choice >


Carbazole-Based Boron Dipyrromethenes (BODIPYs): Facile Synthesis, Structures, and Fine-Tunable Optical Properties.
Org. Lett. 2015, 17, 3090-3093.
Maeda, C.; Todaka, T.; Ema, T.


Quaternary Ammonium Hydroxide as a Metal-free and Halogen-free Catalyst for the Synthesis of Cyclic Carbonates from Epoxides and Carbon Dioxide.
Catal. Sci. Technol. 2015, 5, 2314-2321.
Ema, T.; Fukuhara, K.; Sakai, T.; Ohbo, M.; Bai, F.-Q.; Hasegawa, J.


Highly Active Bifunctional Catalysts Based on m-Phenylene-Bridged Porphyrin Dimer and Trimer Platforms for the Synthesis of Cyclic Carbonates from Carbon Dioxide and Epoxides.
Angew. Chem. Int. Ed. 2015, 54, 134-138.
Maeda, C.; Taniguchi, T.; Ogawa, K.; Ema, T.


23章・第2節「リパーゼのエナンチオ選択性の発現機構:酵素反応の遷移状態の理解と制御」
「有機合成実験法ハンドブック(第2版)」有機合成化学協会編,丸善(2015)
依馬 正

CO2の触媒的化学変換 最新研究が古くからのテーマを切り開く
化学, 2015, 70, 64–65.
前田千尋, 依馬 正


[2014

Bifunctional Porphyrin Catalysts for the Synthesis of Cyclic Carbonates from Epoxides and CO2: Structural Optimization and Mechanistic Study.
J. Am. Chem. Soc. 2014, 136, 15270-15279.
Ema, T.; Miyazaki, Y.; Shimonishi, J.; Maeda, C.; Hasegawa, J.


Selective Anion Sensing by Chiral Macrocyclic Receptors with Multiple Hydrogen-Bonding Sites.
Org. Lett. 2014, 16, 1302-1305.
Ema, T.; Okuda, K.; Watanabe, S.; Yamasaki, T.; Minami, T.; Esipenko, N. A.; Anzenbacher, P., Jr.


Synergistic Effect of Quaternary Ammonium Hydroxide and Crown Ether on the Rapid and Clear Dissolution of Cellulose at Room Temperature.
RSC Advances 2014, 4, 2523-2525.
Ema, T.; Komiyama, T.; Sunami, S.; Sakai, T.


Recent Progress in Catalytic Conversions of Carbon Dioxide.
Catal. Sci. Technol. 2014, 4, 1482-1497.
Maeda, C.; Miyazaki, Y.; Ema, T.
< Back Cover Picture >
< Review >
< Open Access > http://xlink.rsc.org/?doi=C3CY00993A

化学原料として二酸化炭素を使う:現状と展望
ボイラ・ニュース, 2014, (12), 1–3.
依馬 正

[2013

Robust Porphyrin Catalysts Immobilized on Biogenous Iron Oxide for the Repetitive Conversions of Epoxides and CO2 into Cyclic Carbonates.
Green Chem. 2013, 15, 2485-2492.
Ema, T.; Miyazaki, Y.; Taniguchi, T.; Takada, J.

Multifunctional Macrocyclic Receptors as Templates for Aromatic Amino Acids: A Rare Example of a Highly Selective Multi-Input Multi-Output Chemo-“Logic Gate”.
ChemPlusChem 2013, 78, 979-987.
Fraschetti, C.; Filippi, A.; Crestoni, M. E.; Ema, T.; Speranza, M.

Unexpected Behavior of Diastereomeric Ions in the Gas Phase: A Stimulus for Pondering on ee Measurements by ESI-MS.
J. Am. Soc. Mass Spectrom. 2013, 24, 573-578.
Fraschetti, C.; Filippi, A.; Crestoni, M. E.; Ema, T.; Speranza, M.


二酸化炭素固定化のための二官能性ポルフィリン金属錯体触媒の開発
ENEOS Technical Review, 2013, 55, 86–90.
依馬 正


二酸化炭素固定化触媒の開発:協同効果の利用
ファインケミカル, 2013, 42, 18-23.
依馬 正


[2012

Construction of Contiguous Tetrasubstituted Carbon Stereocenters by Intramolecular Crossed Benzoin Reactions Catalyzed by NHC Organocatalyst.
Adv. Synth. Catal. 2012, 354, 3283-3290.
Ema, T.; Akihara, K.; Obayashi, R.; Sakai, T.


Redesign of Enzyme for Improving Catalytic Activity and Enantioselectivity toward Poor Substrates: Manipulation of the Transition State.
Org. Biomol. Chem. 2012, 10, 6299-6308.
Ema, T.; Nakano, Y.; Yoshida, D.; Kamata, S.; Sakai, T.
< Cover Picture >
< Top10 Accessed Article during the Second Quarter of 2013 >

Bifunctional Catalyst for Carbon Dioxide Fixation: Cooperative Double Activation of Epoxides for the Synthesis of Cyclic Carbonates.
Chem. Commun. 2012, 48, 4489-4491.
Ema, T.; Miyazaki, Y.; Koyama, S.; Yano, Y.; Sakai, T.


Biogenous Iron Oxide-immobilized Palladium Catalyst for the Solvent-free Suzuki-Miyaura Coupling Reaction.
Tetrahedron Lett. 2012, 53, 329-332.
Mandai, K.; Korenaga, T.; Ema, T.; Sakai, T.; Furutani, M.; Hashimoto, H.; Takada, J.


Molecular Recognition of Chiral Diporphyrin Receptor with a Macrocyclic Cavity for Intercalation of Aromatic Compounds.
Bull. Chem. Soc. Jpn. 2012, 85, 101-109.
Ema, T.; Ura, N.; Eguchi, K.; Sakai, T.
< Dedicated to Emeritus Professor H. Ogoshi (Kyoto University) on the occasion of his 77th birthday >


Synthetic Macrocyclic Receptors in Chiral Analysis and Separation.
J. Inclusion Phenom. Macrocycl. Chem. 2012, 74, 41-55.
Ema, T.
< HGCS Japan Award of Excellence 2011 (Award Review) >


[2011年]

Highly Active Lipase Immobilized on Biogenous Iron Oxide via Organic Bridging Group: Dramatic Effect of Immobilization Support on Enzymatic Function.
Green Chem. 2011, 13, 3187-3195.
Ema, T.; Miyazaki, Y.; Kozuki, I.; Sakai, T.; Hashimoto, H.; Takada, J.


Chiral Porphyrin Dimer with a Macrocyclic Cavity for Intercalation of Aromatic Guests.
Chem. Commun. 2011, 47, 6090-6092.
Ema, T.; Ura, N.; Eguchi, K.; Ise, Y.; Sakai, T.


[2010

Bifunctional Organocatalyst for Activation of Carbon Dioxide and Epoxide to Produce Cyclic Carbonate: Betaine as a New Catalytic Motif.
Org. Lett. 2010, 12 , 5728-5731.
Tsutsumi, Y.; Yamakawa, K.; Yoshida, M.; Ema, T.; Sakai, T.


Synthesis and Evaluation of Chiral Selectors with Multiple Hydrogen-Bonding Sites in the Macrocyclic Cavities.
J. Org. Chem. 2010, 75, 4492-4500.
Ema, T.; Hamada, K.; Sugita, K.; Nagata, Y.; Sakai, T.; Ohnishi, A.


Chemoenzymatic Synthesis of Optically Active Alcohol and β-Amino-Acid Derivative Containing the Difluoromethylene Group.
J. Mol. Catal. B: Enz. 2010, 66, 198-202.
Ema, T.; Kadoya, T.; Akihara, K.; Sakai, T.


Rational Creation of Mutant Enzyme Showing Remarkable Enhancement of Catalytic Activity and Enantioselectivity toward Poor Substrates.
Chem. Commun. 2010, 46, 5440-5442.
Ema, T.; Kamata, S.; Takeda, M.; Nakano, Y.; Sakai, T.

< Hot Article >

Chemical Modification of Biogenous Iron Oxide to Create an Excellent Enzyme Scaffold.
Org. Biomol. Chem. 2010, 8, 336-338.
Sakai, T.; Miyazaki, Y.; Murakami, A.; Sakamoto, N.; Ema, T.; Hashimoto, H.; Furutani, M.; Nakanishi, M.; Fujii, T.; Takada, J.


第5章・第6節「汎用酵素のエナンチオ選択性の合理的制御」
「酵素利用技術大系:基礎・解析から改変・高機能化・産業利用まで」小宮山眞 監修,エヌ・ティー・エス(2010)
依馬 正

[2009


Stereoselective Synthesis of Bicyclic Tertiary Alcohols with Quaternary Stereocenters via Intramolecular Crossed Benzoin Reactions Catalyzed by N-Heterocyclic Carbenes.
Org. Lett. 2009, 11, 4866-4869.
Ema, T.; Oue, Y.; Akihara, K.; Miyazaki, Y.; Sakai, T.


Empirical Method for Predicting Enantioselectivity in Catalytic Reactions: Demonstration with Lipase and Oxazaborolidine.
Tetrahedron 2009, 65, 9583-9591.
Ema, T.; Ura, N.; Yoshii, M.; Korenaga, T.; Sakai, T.


Highly Enantioselective and Efficient Synthesis of Methyl (R)-o-Chloromandelate, Key Intermediate for Clopidogrel Synthesis, with Recombinant Escherichia coli.
Ema, T.; Okita, N.; Ide, S.; Sakai, T. (contributed authors) In Practical Methods for Biocatalysis and Biotransformations; Whittall, J., Sutton, P.; John-Wiley & Sons: 2009.


第1章・第3節・11「超分子における不斉認識」
「超分子サイエンス&テクノロジー:基礎からイノベーションまで」国武豊喜 監修,エヌ・ティー・エス(2009)
依馬 正

[2008

Tuning the Chiral Cavity of Macrocyclic Receptor for Chiral Recognition and Discrimination.
J. Org. Chem. 2008, 73, 9129-9132.
Ema, T.; Tanida, D.; Hamada, K.; Sakai, T.


Highly Efficient Chemoenzymatic Synthesis of Methyl (R)-o-Chloromandelate, Key Intermediate for Clopidogrel, via Asymmetric Reduction with Recombinant Escherichia coli.
Adv. Synth. Catal. 2008, 350, 2039-2044.
Ema, T.; Ide, S.; Okita, N.; Sakai, T.


Chiral Selector with Multiple Hydrogen-Bonding Sites in a Macrocyclic Cavity.
Org. Lett. 2008, 10, 2365-2368.
Ema, T.; Tanida, D.; Sugita, K.; Sakai, T.; Miyazawa, K.; Ohnishi, A.


Highly Active and Robust Organic-Inorganic Hybrid Catalyst for the Synthesis of Cyclic Carbonates from Carbon Dioxide and Epoxides.
Green Chem. 2008, 10, 345-349.
Sakai, T.; Tsutsumi, Y.; Ema, T.


Biomimetic Trifunctional Organocatalyst Showing a Great Acceleration for the Transesterification between Vinyl Ester and Alcohol.
Chem. Commun. 2008, 957-959.
Ema, T.; Tanida, D.; Matsukawa, T.; Sakai, T.
< Highlight Article in Chemistry World (RSC) >

Lipase-Catalyzed Dynamic Kinetic Resolution Giving Optically ActiveCyanohydrins: Use of Silica-Supported Ammonium Hydroxide and Porous Ceramic-Immobilized Lipase.
Tetrahedron 2008, 64, 2178-2183
Sakai, T.; Wang, K.; Ema, T.


Hydrolase-Catalyzed Kinetic Resolution of 5-[4-(1-Hydroxyethyl)phenyl]-10,15,20-tris(pentafluorophenyl)porphyrin in Ionic Liquids.
Chem. Lett. 2008, 37, 90-91.
Ema, T.; Doi, T.; Sakai, T.


[2007

Versatile and Practical Macrocyclic Reagent with Multiple Hydrogen-Bonding Sites for Chiral Discrimination in NMR.
J. Am. Chem. Soc. 2007, 129, 10591-10596.
Ema, T.; Tanida, D.; Sakai, T.


Highly Enantioselective and Efficient Synthesis of Methyl (R)-o-Chloromandelate with Recombinant E. coli: Toward Practical and Green Access to Clopidogrel.
Org. Biomol. Chem. 2007, 5, 1175-1176.
Ema, T.; Okita, N.; Ide, S.; Sakai, T.


[2006

Versatile and Practical Chiral Shift Reagent with Hydrogen-Bond Donor/Acceptor Sites in a Macrocyclic Cavity.
Org. Lett. 2006, 8, 3773-3775.
Ema, T.; Tanida, D.; Sakai, T.


Asymmetric Reduction of Ketones Using Recombinant E. coli Cells that Produce a Versatile Carbonyl Reductase with High Enantioselectivity and Broad Substrate Specificity
Tetrahedron 2006, 62, 6143-6149.
Ema, T.; Yagasaki, H.; Okita, N.; Takeda, M.; Sakai, T.


Synthesis of Molecular Tweezers bearing Pentafluorophenyl and Several Pendant Aryl Groups. Effective Application of the Modified Suzuki-Miyaura Coupling Reaction
J. Fluorine Chem. 2006, 127, 604-609.
Korenaga, T.; Kosaki, T.; Kawauchi, Y.; Ema, T.; Sakai, T.


汎用生体触媒の機能開拓
化学工業, 2006, 57, 75-79.
依馬 正


[2005

Suzuki-Miyaura Coupling Reaction Using Pentafluorophenylboronic Acid.
Org. Lett. 2005, 7, 4915-4917.
Korenaga, T.; Kosaki, T.; Fukumura, R.; Ema, T.; Sakai, T.


Synthesis of the Molecular Tweezer Containing Pentafluorophenyl Groups and Investigation of the π-π Stacking Interaction for a Pentafluorophenyl Group in a Polar Organic Solvent.
Bull. Chem. Soc. Jpn. 2005, 78, 2175-2179 .
Korenaga, T.; Kawauchi, Y.; Kosaki, T.; Ema, T.; Sakai, T.


Highly Sensitive Chiral Shift Reagent Bearing Two Zinc Porphyrins.
Org. Lett. 2005, 7, 3985-3988.
Ema, T.; Ouchi, N.; Doi, T.; Korenaga, T.; Sakai, T.


Rational Control of Enantioselectivity of Lipase by Site-directed Mutagenesis Based on the Mechanism.
Chem. Commun. 2005, 4650-4651.
Ema, T.; Fujii, T.; Ozaki, M.; Korenaga T.; Sakai, T.


Kinetic Resolution of 5-(Hydroxymethyl)-3-phenyl-2-isoxazoline by using the “Low-temperature Method” with Porous Ceramics-immobilized Lipase.
Tetrahedron: Asymmetry 2005, 16, 1535-1539.
Sakai, T.; Mitsutomi, H.; Korenaga, T.; Ema, T.


Lipase-Catalyzed Resolution of (2R*,3S*)- and (2R*,3R*)-3-Methyl-3-phenyl-2-aziridinemethanol at Low Temperatures and Determination of the Absolute Configurations of the Four Stereoisomers.
J. Org. Chem., 2005, 70, 1369-1375.
Sakai, T.; Liu, Y.; Ohta, H.; Korenaga, T.; Ema, T.


Asymmetric Reduction of a Variety of Ketones with a Recombinant Carbonyl Reductase: Identification of the Gene Encoding a Versatile Biocatalyst.
Tetrahedron: Asymmetry 2005, 16, 1075-1078.
Ema, T.; Yagasaki, H.; Okita, N.; Nishikawa, K.; Korenaga, T.; Sakai, T.

[2004

Reestimation of the Taft's Substituent Constant of the Pentafluorophenyl Group.
J. Org. Chem., 2004, 69, 7340-7343.
Korenaga, T.; Kadowaki, K.; Ema, T.; Sakai, T.


Rational Strategies for Highly Enantioselective Lipase-Catalyzed Kinetic Resolution of Very Bulky Chiral Compounds: Substrate Design and High-Temperature Biocatalysis. (Review)
Tetrahedron:Asymmetry, 2004, 15, 2765-2770.
Ema, T.


Mechanism of Enantioselectivity of Lipases and Other Synthetically Useful Hydrolases. (Review)
Curr. Org. Chem. 2004, 8, 1009-1025.
Ema, T.


The Effect of Temperature on the Lipase-Catalyzed Asymmetric Protonation of 1-Acetoxy-2-methylcyclohexene Giving (R)-2-Methylcyclohexanone.
Tetrahedron: Asymmetry 2004, 15, 1929-1932.
Sakai, T.; Matsuda, A.; Tanaka, Y.; Korenaga, T.; Ema, T.


Synthesis of Enantiomerically Pure (R,R)- and (S,S)-1,2-Bis(pentafluorophenyl)ethane-1,2-diamine and Evaluation of the pKa Value by ab initio Calculations.
Bull. Chem. Soc. Jpn. 2004, 77, 1001-1008.
Sakai, T.; Korenaga, T.; Washio, N.; Nishio, Y.; Minami, S.; Ema, T.


リパーゼ反応の合理性の追究と120℃から-40℃までの極限温度下における酵素反応
生物工学会誌, 2004, 82, 241-243.
依馬 正


[2003

Highly Enantioselective Lipase-Catalyzed Reactions at High Temperatures up to 120 °C in Organic Solvent.
Tetrahedron: Asymmetry 2003, 14, 3943-3947.
Ema, T.; Kageyama, M.; Korenaga, T.; Sakai, T.

Practical Resolution of 3-Phenyl-2H-azirine-2-methanol at Very Low Temperature by Using Lipase Immobilized on Porous Ceramic and Optimized Acylating Agent.
Bull. Chem. Soc. Jpn. 2003, 76, 1819-1821.
Sakai, T.; Matsuda, A.; Korenaga, T.; Ema, T.


Intermolecular Oxygen Atom-pi Interaction in the Crystal Packing of Chiral Amino Alcohol Bearing a Pentafluorophenyl Group.
J. Fluorine Chem. 2003, 122, 201-205.
Korenaga, T.; Tanaka, H.; Ema, T.; Sakai, T.

Transition-State Models Are Useful for Versatile Biocatalysts: Kinetics and Thermodynamics of Enantioselective Acylations of Secondary Alcohols Catalyzed by Lipase and Subtilisin.
J. Mol. Catal. B: Enz. 2003, 22, 181-192.
Ema, T.; Yamaguchi, K.; Wakasa, Y.; Yabe, A.; Okada, R.; Fukumoto, M.; Yano, F.; Korenaga, T.; Utaka, M.; Sakai, T.

Enhancement of the Efficiency of the Low Temperature Method for Kinetic Resolution of Primary Alcohols by Optimizing the Organic Bridges in Porous Ceramic-Immobilized Lipase.
Bull. Chem. Soc. Jpn. 2003, 76, 1441-1446.
Sakai, T.; Hayashi, K.; Yano, F.; Takami M.; Ino, M.; Korenaga, T.; Ema, T.

[2002

Mechanism-Based Enzymatic Method for Reliable Determination of Absolute Configuration of Chiral 1-Substituted Ethanols: Combination with NMR Method.
Tetrahedron: Asymmetry 2002, 13, 1223-1229.
Ema, T.; Yoshii, M.; Korenaga, T.; Sakai, T.

5-[4-(1-Hydroxyethyl)phenyl]-10,15,20-triphenylporphyrin as a Probe of the Transition-State Conformation in Hydrolase-Catalyzed Enantioselective Transesterifications.
J. Org. Chem. 2002, 67, 2144-2151.
Ema, T.; Jittani, M.; Furuie, K.; Utaka, M.; Sakai, T.

[2001年]

High Enantioselectivity and Broad Substrate Specificity of a Carbonyl Reductase: Toward a Versatile Biocatalyst.
J. Org. Chem. 2001, 66, 8682-8684.
Ema, T.; Moriya, H.; Kofukuda, T.; Ishida, T.; Maehara, K.; Utaka, M.; Sakai, T.

[2000年]

Compensation Effect between Differential Activation Enthalpy and Entropy in Subtilisin-Catalyzed Kinetic Resolutions of Secondary Alcohols.
Chem. Lett. 2000, 782-783.
Ema, T.; Yamaguchi, K.; Wakasa, Y.; Tanaka, N.; Utaka, M.; Sakai, T.

Lipase-Catalyzed Transesterification of 2-Hydroxy-2-(pentafluorophenyl) acetonitrile Leading to (1R,2R)- and (1S,2S)-Bis(pentafluorophenyl)-ethane-1,2-diol.
J. Org. Chem. 2000, 65, 2740-2747.
Sakai, T. ; Miki, Y. ; Tsuboi, M. ; Takeuchi, H. ; Ema, T.; Uneyama, K. ; Utaka, M.

加水分解酵素を用いた不斉アルコールの速度論的光学分割: エナンチオ選択性の発現機構
有機合成化学協会誌, 2000, 58, 691-698.
依馬 正, 酒井貴志

加水分解酵素のエナンチオ選択性の発現機構
バイオサイエンスとインダストリー, 2000, 58, 493-494.
依馬 正

[1999年]

Transition-State Model for Subtilisin-Catalyzed Transesterifications of Secondary Alcohols.
Tetrahedron Lett. 1999, 40, 4367-4370.
Ema, T.; Okada, R.; Fukumoto, M.; Jittani, M.; Ishida, M.; Furuie, K.; Yamaguchi, K.; Sakai, T.; Utaka, M.

酵素反応の立体選択性の起源-遷移状態における不斉識別-
(特集・化学のフロンティア'99- はばたけ若き研究者たち-)
化学と工業, 1999, 52, 163-166.
依馬 正

[1998年]

Low-Temperature Method for Enhancement of Enantioselectivity in the Lipase-Catalyzed Kinetic Resolutions of Solketal and Some Chiral Alcohols.
Tetrahedron Lett. 1998, 39, 7881-7884.
Sakai, T.; Kishimoto, T.; Tanaka, Y.; Ema, T.; Utaka, M.

Lipase-Catalyzed Kinetic Resolution of Large Secondary Alcohols Having Tetraphenylporphyrin.
Tetrahedron Lett. 1998, 39, 6311-6314.
Ema, T.; Jittani, M.; Sakai, T.; Utaka, M.

Control of Enantioselectivity in the Baker's Yeast Asymmetric Reduction of g-Chloro b-Diketones to g-Chloro (S)-b-Hydroxy Ketones.
Tetrahedron: Asymmetry 1998, 9, 2681-2692.
Cui, J.-N.; Ema, T.; Sakai, T.; Utaka, M.

Lipase-Catalyzed Kinetic Resolution of 2-Acyloxy-2-(pentafluorophenyl)acetonitrile.
Tetrahedron Lett. 1998, 39, 5233-5236.
Sakai, T.; Miki, Y.; Nakatani, M.; Ema, T.; Uneyama, K.; Utaka, M.

Highly Enantioselective Reduction of Carbonyl Compounds Using a Reductase Purified from Bakers' Yeast.
J. Org. Chem. 1998, 63, 4996-5000.
Ema, T.; Sugiyama, Y.; Fukumoto, M.; Moriya, H.; Cui, J.-N.; Sakai, T.; Utaka, M.

Origin of the Enantioselectivity of Lipases Explained by a Stereo-Sensing Mechanism Operative at the Transition State.
Bull. Chem. Soc. Jpn. 1998, 71, 443-453.
Ema, T.; Kobayashi, J.; Maeno, S.; Sakai, T.; Utaka, M.

[1997年]

Enhancement of the Enantioselectivity in Lipase-Catalyzed Kinetic Resolutions of 2H-Azirine-2-methanol by Lowering the Temperature to -40 C.
J. Org. Chem. 1997, 62, 4906-4907.
Sakai, T.; Kawabata, I.; Kishimoto, T.; Ema, T.; Utaka, M.

Highly Regio- and Enantioselective Reduction of 1-Chloro-2,4-alkanediones Using Bakers' Yeast: Effects of Organic Solvents as Additives.
Tetrahedron Lett. 1997, 38, 3021-3024.
Cui, J.-N.; Teraoka, R.; Ema, T.; Sakai.T.; Utaka, M.

Lipase-Catalyzed Efficient Kinetic Resolution of 3-Hydroxy-3-(pentafluoro-phenyl)propionitrile and Related Compounds.
Tetrahedron Lett. 1997, 38, 1987-1990.
Sakai.T.; Takayama, T.; Ohkawa, T.; Yoshio, O.; Ema, T.; Utaka, M.

New Optically Active Diporphyrin Having a Chiral Cyclophane as a Spacer.
Chem. Lett. 1997, 487-488.
Ema, T.; Misawa, S.; Nemugaki, S.; Sakai, T.; Utaka, M.

[1996年]

Highly Efficient and Convenient Regeneration of NADPH for Asymmetric Reduction Using Bakers' Yeast Cell Free Extract.
Chem. Lett. 1996, 1079-1080.
Utaka, M.; Yano, T.; Ema, T.; Sakai, T.

Kinetic Resolution of Racemic 2-Substituted 3-Cyclopenten-1-ols by Lipase-Catalyzed Transesterifications: A Rational Strategy to Improve Enantioselectivity.
J. Org. Chem. 1996, 61, 8610-8616.
Ema, T.; Maeno, S.; Takaya, Y.; Sakai, T.; Utaka, M.

Significant Effect of Acyl Groups on Enantioselectivity in Lipase-Catalyzed Transesterifications.
Tetrahedron: Asymmetry 1996, 7, 625-628.
Ema, T.; Maeno, S.; Takaya, Y.; Sakai, T.; Utaka, M.

[1995年]

Unusual Picosecond 1(p,p*) Deactivation of Ruffled Nonplanar Porphyrins.
Chem. Phys. Lett. 1995, 245, 441-447.
Gentemann, S.; Medforth, C. J.; Ema, T.; Nelson, N. Y.; Smith, K. M.; Fajer, J.; Holten, D.

Ruffling in a Series of Nickel(II) meso-Tetrasubstituted Porphyrins as a Model for the Conserved Ruffling of the Heme in Cytochromes c.
J. Am. Chem. Soc. 1995, 117, 11085-11097.
Jentzen, W.; Simpson, M. C.; Hobbs, J. D.; Song, X.; Ema, T.; Nelson, N. Y.; Medforth, C. J.; Smith, K. M.; Veyrat, M.; Mazzanti, M.; Ramasseul, R.; Marchon, J.-C.; Takeuchi, T.; Goddard, W. A.; Shelnutt, J. A.

Synthesis and CD Spectrum of Chiral Porphyrin Dimer.
Tetrahedron Lett. 1995, 36, 5905-5908.
Ema, T.; Nemugaki, S; Tsuboi, S.; Utaka, M.

Complexation-induced Catalysis in Zinc Insertion into Cationic Porphyrin.
Chem. Lett. 1995, 941-942.
Mizuani, T.; Koyama H.; Ema, T.; Nomura, A.; Yoshida T.; Ogoshi, H.

Molecular Recognition: New Chiral Metalloporphyrins as Receptor Models.
Supramol. Chem. 1995, 6, 115-124.
Ogoshi, H.; Ema, T.; Kato, Y.; Mizutani, T.; Kuroda, Y.

Crystal Structure of a Remarkably Ruffled Nonplanar Porphyrin (Pyridine)[5,10,15,20-Tetra(tert-butyl)porphyrinato]zinc(II).
J. Chem. Soc., Chem. Commun. 1995, 733-734.
Senge, M. O.; Ema, T.; Smith, K. M.

Restricted Internal Rotation of Amino Acid Esters. Quantitative Evaluation of Rigidity of a Molecule in terms of Internal Rotational Entropy.
Tetrahedron 1995, 51, 473-484.
Mizutani, T.; Ema, T.; Ogoshi, H.

[1994年]

5,10,15,20-Tetra-tert-butylporphyrin and Its Remarkable Reactivity in the 5- and 15-Positions.
Angew. Chem., Int. Ed. Engl. 1994, 33, 1879-1881.
Ema, T.; Senge, M. O.; Nelson, N. Y.; Ogoshi, H.; Smith, K. M.

Design and Synthesis of a Trifunctional Chiral Porphyrin with C2 Symmetry as a Chiral Recognition Host for Amino Acid Esters.
J. Am. Chem. Soc. 1994, 116, 4240-4250.
Mizutani, T.; Ema, T.; Tomita, T.; Kuroda, Y.; Ogoshi, H.

Mechanism of Induced Circular Dichroism of Amino Acid Ester-Porphyrin Supramolecular Systems. Implications to the Origin of the Circular Dichroism of Hemoprotein.
Inorg. Chem. 1994, 33, 3558-3566.
Mizutani, T.; Ema, T.; Yoshida, T.; Renne, T.; Ogoshi, H.

分子間相互作用を制御した不斉分子認識
油化学, 1994, 43, 769-778.
生越久靖, 依馬 正, 水谷 義

[1993年]

Recognition of a-Amino Acid Esters by Zinc Porphyrin Derivatives via Coordination and Hydrogen Bonding Interactions. Evidence for Two-Point Fixation from Thermodynamic and Induced Circular Dichroism Spectroscopic Studies.
Inorg. Chem. 1993, 32, 2072-2077.
Mizutani, T.; Ema, T.; Yoshida, T.; Kuroda, Y.; Ogoshi, H.

Recognition of Chirality and Residual Groups of Amino Acid Esters using New Trifunctional Chiral Porphyrins with C2 Symmetry.
J. Chem. Soc., Chem. Commun. 1993, 520-522.
Mizutani, T.; Ema, T.; Tomita, T.; Kuroda, Y.; Ogoshi, H.

[1992年]

Synthesis and Photoreaction of 1,2,3,4-Tetra-t-butylnaphthalene: A Highly Crowded Naphthalene Derivative and Its Valenceisomers.
Tetrahedron Lett. 1992, 33, 1619-1620.
Miki, S.; Ema, T.; Shimizu, R.; Nakatsuji, H.; Yoshida, Z.

[1991年]

Selective Syntheses of Unsymmetrical meso-Arylporphyrins.
Tetrahedron Lett. 1991, 32, 4529-4532.
Ema, T.; Kuroda, Y.; Ogoshi, H.

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