論 文 発 表  


Synthetically Useful Variants of Industrial Lipases from Burkholderia cepacia and Pseudomonas fluorescens.
Org. Biomol. Chem. 2017, 15, in press.
Yoshida, K.; Ono, M.; Yamamoto, T.; Utsumi, T.; Koikeda, S.; Ema, T.

Carbazole-Based BODIPYs with Ethynyl Substituents at the Boron Center: Solid-State Excimer Fluorescence in the VIS/NIR Region.
Org. Biomol. Chem. 2017, 15, in press.
Maeda, C.; Nagahata, K.; Ema, T.

Chiral Macrocyclic Organocatalysts for Kinetic Resolution of Disubstituted Epoxides with Carbon Dioxide.
Org. Lett. 2017, 19, 4070-4073.
Ema, T.; Yokoyama, M.; Watanabe, S.; Sasaki, S.; Ota, H.; Takaishi, K.

Spectroscopic Discrimination of Diastereomeric Complexes Involving an Axially Chiral Receptor.
ChemPhysChem 2017, 18, 2475-2481.
Filippi, A.; Fraschetti, C.; Guarcini, L.; Zazza, C.; Ema, T.; Speranza, M.

Helical Oligonaphthodioxepins Showing Intense CPL in Solution and in the Solid State.
Chem. Eur. J. 2017, 23, 9249-9252.
Takaishi, K.; Yamamoto, T.; Hinoide, S.; Ema, T.
< Hot Paper >

Electronic Tuning of Zinc Porphyrin Catalysts for the Conversion of Epoxides and CO2 into Cyclic Carbonates.
ChemCatChem 2017, 9, 946-949.
Maeda, C.; Sasaki, S.; Ema, T.

Magnetic Attachment of Lipase Immobilized on Bacteriogenic Iron Oxide Inside a Microtube Reactor for the Kinetic Resolution of Secondary Alcohols.
Synlett 2017, 28, 805-810.
Mandai, K.; Fukuda, T.; Miyazaki, Y.; Hashimoto, H.; Mandai, H.; Ema, T.; Takada, J.; Suga, S.


Intramolecular Electronic Coupling in the Thiophene-Bridged Carbazole-Based Diporphyrin.
Org. Lett. 2016, 18, 6070-6073.
Maeda, C.; Takata, M.; Honsho, A.; Ema, T.
< Synfacts >

Solvent-Free Benzoin and Stetter Reactions with a Small Amount of NHC Catalyst in the Liquid or Semisolid State.
Org. Lett. 2016, 18, 5764-5767.
Ema, T.; Nanjo, Y.; Shiratori, S.; Terao, Y.; Kimura, R.

Color-Tunable Solid-State Fluorescence from Carbazole-Based BODIPYs.
Chem. Eur. J. 2016, 22, 7508-7513.
Maeda, C.; Todaka, T.; Ueda, T.; Ema, T.

Highly Active and Robust Metalloporphyrin Catalysts for the Synthesis of Cyclic Carbonates from a Broad Range of Epoxides and Carbon Dioxide.
Chem. Eur. J. 2016, 22, 6556-6563.
Maeda, C.; Shimonishi, J.; Miyazaki, R.; Hasegawa, J.; Ema, T.
< Hot Paper >
< Frontispiece >

Determination of Enantiomeric Excess of Carboxylates by Fluorescent Macrocyclic Sensors.
Chem. Sci. 2016, 7, 2016-2022.
Akdeniz, A.; Minami, T.; Watanabe, S.; Yokoyama, M.; Ema, T.; Anzenbacher, P., Jr.

Theoretical Study on Highly Active Bifunctional Metalloporphyrin Catalysts for the Coupling Reaction of Epoxides with Carbon Dioxide.
Chem. Rec. 2016, 16, 2260-2267.
Hasegawa, J.; Miyazaki, R.; Maeda, C.; Ema, T.
< Account >

Double Mutant Lipase with Enhanced Activity and Enantioselectivity for Bulky Secondary Alcohols.
Ema, T.; Kamata, S.; Nakano, Y.; Yoshida, D.; Sakai, T. (contributed authors) In Practical Methods for Biocatalysis and Biotransformations 3; Whittall, J., Sutton, P., Kroutil, W., Eds.; Wiley: West Sussex, 2016.

有機合成化学協会誌, 2016, 74, 814-823.
前田千尋, 依馬 正


Chemical Modification of Lipase for Rational Enhancement of Enantioselectivity.
Chem. Lett. 2015, 44, 1374-1376.
Ema, T.; Inoue, H.
< Editor's Choice >

Carbazole-Based Boron Dipyrromethenes (BODIPYs): Facile Synthesis, Structures, and Fine-Tunable Optical Properties.
Org. Lett. 2015, 17, 3090-3093.
Maeda, C.; Todaka, T.; Ema, T.

Quaternary Ammonium Hydroxide as a Metal-free and Halogen-free Catalyst for the Synthesis of Cyclic Carbonates from Epoxides and Carbon Dioxide.
Catal. Sci. Technol. 2015, 5, 2314-2321.
Ema, T.; Fukuhara, K.; Sakai, T.; Ohbo, M.; Bai, F.-Q.; Hasegawa, J.

Highly Active Bifunctional Catalysts Based on m-Phenylene-Bridged Porphyrin Dimer and Trimer Platforms for the Synthesis of Cyclic Carbonates from Carbon Dioxide and Epoxides.
Angew. Chem. Int. Ed. 2015, 54, 134-138.
Maeda, C.; Taniguchi, T.; Ogawa, K.; Ema, T.

依馬 正

CO2の触媒的化学変換 最新研究が古くからのテーマを切り開く
化学, 2015, 70, 64–65.
前田千尋, 依馬 正


Bifunctional Porphyrin Catalysts for the Synthesis of Cyclic Carbonates from Epoxides and CO2: Structural Optimization and Mechanistic Study.
J. Am. Chem. Soc. 2014, 136, 15270-15279.
Ema, T.; Miyazaki, Y.; Shimonishi, J.; Maeda, C.; Hasegawa, J.

Selective Anion Sensing by Chiral Macrocyclic Receptors with Multiple Hydrogen-Bonding Sites.
Org. Lett. 2014, 16, 1302-1305.
Ema, T.; Okuda, K.; Watanabe, S.; Yamasaki, T.; Minami, T.; Esipenko, N. A.; Anzenbacher, P., Jr.

Synergistic Effect of Quaternary Ammonium Hydroxide and Crown Ether on the Rapid and Clear Dissolution of Cellulose at Room Temperature.
RSC Advances 2014, 4, 2523-2525.
Ema, T.; Komiyama, T.; Sunami, S.; Sakai, T.

Recent Progress in Catalytic Conversions of Carbon Dioxide.
Catal. Sci. Technol. 2014, 4, 1482-1497.
Maeda, C.; Miyazaki, Y.; Ema, T.
< Back Cover Picture >
< Review >
< Open Access > http://xlink.rsc.org/?doi=C3CY00993A

ボイラ・ニュース, 2014, (12), 1–3.
依馬 正


Robust Porphyrin Catalysts Immobilized on Biogenous Iron Oxide for the Repetitive Conversions of Epoxides and CO2 into Cyclic Carbonates.
Green Chem. 2013, 15, 2485-2492.
Ema, T.; Miyazaki, Y.; Taniguchi, T.; Takada, J.

Multifunctional Macrocyclic Receptors as Templates for Aromatic Amino Acids: A Rare Example of a Highly Selective Multi-Input Multi-Output Chemo-“Logic Gate”.
ChemPlusChem 2013, 78, 979-987.
Fraschetti, C.; Filippi, A.; Crestoni, M. E.; Ema, T.; Speranza, M.

Unexpected Behavior of Diastereomeric Ions in the Gas Phase: A Stimulus for Pondering on ee Measurements by ESI-MS.
J. Am. Soc. Mass Spectrom. 2013, 24, 573-578.
Fraschetti, C.; Filippi, A.; Crestoni, M. E.; Ema, T.; Speranza, M.

ENEOS Technical Review, 2013, 55, 86–90.
依馬 正

ファインケミカル, 2013, 42, 18-23.
依馬 正


Construction of Contiguous Tetrasubstituted Carbon Stereocenters by Intramolecular Crossed Benzoin Reactions Catalyzed by NHC Organocatalyst.
Adv. Synth. Catal. 2012, 354, 3283-3290.
Ema, T.; Akihara, K.; Obayashi, R.; Sakai, T.

Redesign of Enzyme for Improving Catalytic Activity and Enantioselectivity toward Poor Substrates: Manipulation of the Transition State.
Org. Biomol. Chem. 2012, 10, 6299-6308.
Ema, T.; Nakano, Y.; Yoshida, D.; Kamata, S.; Sakai, T.
< Cover Picture >
< Top10 Accessed Article during the Second Quarter of 2013 >

Bifunctional Catalyst for Carbon Dioxide Fixation: Cooperative Double Activation of Epoxides for the Synthesis of Cyclic Carbonates.
Chem. Commun. 2012, 48, 4489-4491.
Ema, T.; Miyazaki, Y.; Koyama, S.; Yano, Y.; Sakai, T.

Biogenous Iron Oxide-immobilized Palladium Catalyst for the Solvent-free Suzuki-Miyaura Coupling Reaction.
Tetrahedron Lett. 2012, 53, 329-332.
Mandai, K.; Korenaga, T.; Ema, T.; Sakai, T.; Furutani, M.; Hashimoto, H.; Takada, J.

Molecular Recognition of Chiral Diporphyrin Receptor with a Macrocyclic Cavity for Intercalation of Aromatic Compounds.
Bull. Chem. Soc. Jpn. 2012, 85, 101-109.
Ema, T.; Ura, N.; Eguchi, K.; Sakai, T.
< Dedicated to Emeritus Professor H. Ogoshi (Kyoto University) on the occasion of his 77th birthday >

Synthetic Macrocyclic Receptors in Chiral Analysis and Separation.
J. Inclusion Phenom. Macrocycl. Chem. 2012, 74, 41-55.
Ema, T.
< HGCS Japan Award of Excellence 2011 (Award Review) >


Highly Active Lipase Immobilized on Biogenous Iron Oxide via Organic Bridging Group: Dramatic Effect of Immobilization Support on Enzymatic Function.
Green Chem. 2011, 13, 3187-3195.
Ema, T.; Miyazaki, Y.; Kozuki, I.; Sakai, T.; Hashimoto, H.; Takada, J.

Chiral Porphyrin Dimer with a Macrocyclic Cavity for Intercalation of Aromatic Guests.
Chem. Commun. 2011, 47, 6090-6092.
Ema, T.; Ura, N.; Eguchi, K.; Ise, Y.; Sakai, T.


Bifunctional Organocatalyst for Activation of Carbon Dioxide and Epoxide to Produce Cyclic Carbonate: Betaine as a New Catalytic Motif.
Org. Lett. 2010, 12 , 5728-5731.
Tsutsumi, Y.; Yamakawa, K.; Yoshida, M.; Ema, T.; Sakai, T.

Synthesis and Evaluation of Chiral Selectors with Multiple Hydrogen-Bonding Sites in the Macrocyclic Cavities.
J. Org. Chem. 2010, 75, 4492-4500.
Ema, T.; Hamada, K.; Sugita, K.; Nagata, Y.; Sakai, T.; Ohnishi, A.

Chemoenzymatic Synthesis of Optically Active Alcohol and β-Amino-Acid Derivative Containing the Difluoromethylene Group.
J. Mol. Catal. B: Enz. 2010, 66, 198-202.
Ema, T.; Kadoya, T.; Akihara, K.; Sakai, T.

Rational Creation of Mutant Enzyme Showing Remarkable Enhancement of Catalytic Activity and Enantioselectivity toward Poor Substrates.
Chem. Commun. 2010, 46, 5440-5442.
Ema, T.; Kamata, S.; Takeda, M.; Nakano, Y.; Sakai, T.

< Hot Article >

Chemical Modification of Biogenous Iron Oxide to Create an Excellent Enzyme Scaffold.
Org. Biomol. Chem. 2010, 8, 336-338.
Sakai, T.; Miyazaki, Y.; Murakami, A.; Sakamoto, N.; Ema, T.; Hashimoto, H.; Furutani, M.; Nakanishi, M.; Fujii, T.; Takada, J.

「酵素利用技術大系:基礎・解析から改変・高機能化・産業利用まで」小宮山眞 監修,エヌ・ティー・エス(2010)
依馬 正


Stereoselective Synthesis of Bicyclic Tertiary Alcohols with Quaternary Stereocenters via Intramolecular Crossed Benzoin Reactions Catalyzed by N-Heterocyclic Carbenes.
Org. Lett. 2009, 11, 4866-4869.
Ema, T.; Oue, Y.; Akihara, K.; Miyazaki, Y.; Sakai, T.

Empirical Method for Predicting Enantioselectivity in Catalytic Reactions: Demonstration with Lipase and Oxazaborolidine.
Tetrahedron 2009, 65, 9583-9591.
Ema, T.; Ura, N.; Yoshii, M.; Korenaga, T.; Sakai, T.

Highly Enantioselective and Efficient Synthesis of Methyl (R)-o-Chloromandelate, Key Intermediate for Clopidogrel Synthesis, with Recombinant Escherichia coli.
Ema, T.; Okita, N.; Ide, S.; Sakai, T. (contributed authors) In Practical Methods for Biocatalysis and Biotransformations; Whittall, J., Sutton, P.; John-Wiley & Sons: 2009.

「超分子サイエンス&テクノロジー:基礎からイノベーションまで」国武豊喜 監修,エヌ・ティー・エス(2009)
依馬 正


Tuning the Chiral Cavity of Macrocyclic Receptor for Chiral Recognition and Discrimination.
J. Org. Chem. 2008, 73, 9129-9132.
Ema, T.; Tanida, D.; Hamada, K.; Sakai, T.

Highly Efficient Chemoenzymatic Synthesis of Methyl (R)-o-Chloromandelate, Key Intermediate for Clopidogrel, via Asymmetric Reduction with Recombinant Escherichia coli.
Adv. Synth. Catal. 2008, 350, 2039-2044.
Ema, T.; Ide, S.; Okita, N.; Sakai, T.

Chiral Selector with Multiple Hydrogen-Bonding Sites in a Macrocyclic Cavity.
Org. Lett. 2008, 10, 2365-2368.
Ema, T.; Tanida, D.; Sugita, K.; Sakai, T.; Miyazawa, K.; Ohnishi, A.

Highly Active and Robust Organic-Inorganic Hybrid Catalyst for the Synthesis of Cyclic Carbonates from Carbon Dioxide and Epoxides.
Green Chem. 2008, 10, 345-349.
Sakai, T.; Tsutsumi, Y.; Ema, T.

Biomimetic Trifunctional Organocatalyst Showing a Great Acceleration for the Transesterification between Vinyl Ester and Alcohol.
Chem. Commun. 2008, 957-959.
Ema, T.; Tanida, D.; Matsukawa, T.; Sakai, T.
< Highlight Article in Chemistry World (RSC) >

Lipase-Catalyzed Dynamic Kinetic Resolution Giving Optically ActiveCyanohydrins: Use of Silica-Supported Ammonium Hydroxide and Porous Ceramic-Immobilized Lipase.
Tetrahedron 2008, 64, 2178-2183
Sakai, T.; Wang, K.; Ema, T.

Hydrolase-Catalyzed Kinetic Resolution of 5-[4-(1-Hydroxyethyl)phenyl]-10,15,20-tris(pentafluorophenyl)porphyrin in Ionic Liquids.
Chem. Lett. 2008, 37, 90-91.
Ema, T.; Doi, T.; Sakai, T.


Versatile and Practical Macrocyclic Reagent with Multiple Hydrogen-Bonding Sites for Chiral Discrimination in NMR.
J. Am. Chem. Soc. 2007, 129, 10591-10596.
Ema, T.; Tanida, D.; Sakai, T.

Highly Enantioselective and Efficient Synthesis of Methyl (R)-o-Chloromandelate with Recombinant E. coli: Toward Practical and Green Access to Clopidogrel.
Org. Biomol. Chem. 2007, 5, 1175-1176.
Ema, T.; Okita, N.; Ide, S.; Sakai, T.


Versatile and Practical Chiral Shift Reagent with Hydrogen-Bond Donor/Acceptor Sites in a Macrocyclic Cavity.
Org. Lett. 2006, 8, 3773-3775.
Ema, T.; Tanida, D.; Sakai, T.

Asymmetric Reduction of Ketones Using Recombinant E. coli Cells that Produce a Versatile Carbonyl Reductase with High Enantioselectivity and Broad Substrate Specificity
Tetrahedron 2006, 62, 6143-6149.
Ema, T.; Yagasaki, H.; Okita, N.; Takeda, M.; Sakai, T.

Synthesis of Molecular Tweezers bearing Pentafluorophenyl and Several Pendant Aryl Groups. Effective Application of the Modified Suzuki-Miyaura Coupling Reaction
J. Fluorine Chem. 2006, 127, 604-609.
Korenaga, T.; Kosaki, T.; Kawauchi, Y.; Ema, T.; Sakai, T.

化学工業, 2006, 57, 75-79.
依馬 正


Suzuki-Miyaura Coupling Reaction Using Pentafluorophenylboronic Acid.
Org. Lett. 2005, 7, 4915-4917.
Korenaga, T.; Kosaki, T.; Fukumura, R.; Ema, T.; Sakai, T.

Synthesis of the Molecular Tweezer Containing Pentafluorophenyl Groups and Investigation of the π-π Stacking Interaction for a Pentafluorophenyl Group in a Polar Organic Solvent.
Bull. Chem. Soc. Jpn. 2005, 78, 2175-2179 .
Korenaga, T.; Kawauchi, Y.; Kosaki, T.; Ema, T.; Sakai, T.

Highly Sensitive Chiral Shift Reagent Bearing Two Zinc Porphyrins.
Org. Lett. 2005, 7, 3985-3988.
Ema, T.; Ouchi, N.; Doi, T.; Korenaga, T.; Sakai, T.

Rational Control of Enantioselectivity of Lipase by Site-directed Mutagenesis Based on the Mechanism.
Chem. Commun. 2005, 4650-4651.
Ema, T.; Fujii, T.; Ozaki, M.; Korenaga T.; Sakai, T.

Kinetic Resolution of 5-(Hydroxymethyl)-3-phenyl-2-isoxazoline by using the “Low-temperature Method” with Porous Ceramics-immobilized Lipase.
Tetrahedron: Asymmetry 2005, 16, 1535-1539.
Sakai, T.; Mitsutomi, H.; Korenaga, T.; Ema, T.

Lipase-Catalyzed Resolution of (2R*,3S*)- and (2R*,3R*)-3-Methyl-3-phenyl-2-aziridinemethanol at Low Temperatures and Determination of the Absolute Configurations of the Four Stereoisomers.
J. Org. Chem., 2005, 70, 1369-1375.
Sakai, T.; Liu, Y.; Ohta, H.; Korenaga, T.; Ema, T.

Asymmetric Reduction of a Variety of Ketones with a Recombinant Carbonyl Reductase: Identification of the Gene Encoding a Versatile Biocatalyst.
Tetrahedron: Asymmetry 2005, 16, 1075-1078.
Ema, T.; Yagasaki, H.; Okita, N.; Nishikawa, K.; Korenaga, T.; Sakai, T.


Reestimation of the Taft's Substituent Constant of the Pentafluorophenyl Group.
J. Org. Chem., 2004, 69, 7340-7343.
Korenaga, T.; Kadowaki, K.; Ema, T.; Sakai, T.

Rational Strategies for Highly Enantioselective Lipase-Catalyzed Kinetic Resolution of Very Bulky Chiral Compounds: Substrate Design and High-Temperature Biocatalysis. (Review)
Tetrahedron:Asymmetry, 2004, 15, 2765-2770.
Ema, T.

Mechanism of Enantioselectivity of Lipases and Other Synthetically Useful Hydrolases. (Review)
Curr. Org. Chem. 2004, 8, 1009-1025.
Ema, T.

The Effect of Temperature on the Lipase-Catalyzed Asymmetric Protonation of 1-Acetoxy-2-methylcyclohexene Giving (R)-2-Methylcyclohexanone.
Tetrahedron: Asymmetry 2004, 15, 1929-1932.
Sakai, T.; Matsuda, A.; Tanaka, Y.; Korenaga, T.; Ema, T.

Synthesis of Enantiomerically Pure (R,R)- and (S,S)-1,2-Bis(pentafluorophenyl)ethane-1,2-diamine and Evaluation of the pKa Value by ab initio Calculations.
Bull. Chem. Soc. Jpn. 2004, 77, 1001-1008.
Sakai, T.; Korenaga, T.; Washio, N.; Nishio, Y.; Minami, S.; Ema, T.

生物工学会誌, 2004, 82, 241-243.
依馬 正


Highly Enantioselective Lipase-Catalyzed Reactions at High Temperatures up to 120 °C in Organic Solvent.
Tetrahedron: Asymmetry 2003, 14, 3943-3947.
Ema, T.; Kageyama, M.; Korenaga, T.; Sakai, T.

Practical Resolution of 3-Phenyl-2H-azirine-2-methanol at Very Low Temperature by Using Lipase Immobilized on Porous Ceramic and Optimized Acylating Agent.
Bull. Chem. Soc. Jpn. 2003, 76, 1819-1821.
Sakai, T.; Matsuda, A.; Korenaga, T.; Ema, T.

Intermolecular Oxygen Atom-pi Interaction in the Crystal Packing of Chiral Amino Alcohol Bearing a Pentafluorophenyl Group.
J. Fluorine Chem. 2003, 122, 201-205.
Korenaga, T.; Tanaka, H.; Ema, T.; Sakai, T.

Transition-State Models Are Useful for Versatile Biocatalysts: Kinetics and Thermodynamics of Enantioselective Acylations of Secondary Alcohols Catalyzed by Lipase and Subtilisin.
J. Mol. Catal. B: Enz. 2003, 22, 181-192.
Ema, T.; Yamaguchi, K.; Wakasa, Y.; Yabe, A.; Okada, R.; Fukumoto, M.; Yano, F.; Korenaga, T.; Utaka, M.; Sakai, T.

Enhancement of the Efficiency of the Low Temperature Method for Kinetic Resolution of Primary Alcohols by Optimizing the Organic Bridges in Porous Ceramic-Immobilized Lipase.
Bull. Chem. Soc. Jpn. 2003, 76, 1441-1446.
Sakai, T.; Hayashi, K.; Yano, F.; Takami M.; Ino, M.; Korenaga, T.; Ema, T.


Mechanism-Based Enzymatic Method for Reliable Determination of Absolute Configuration of Chiral 1-Substituted Ethanols: Combination with NMR Method.
Tetrahedron: Asymmetry 2002, 13, 1223-1229.
Ema, T.; Yoshii, M.; Korenaga, T.; Sakai, T.

5-[4-(1-Hydroxyethyl)phenyl]-10,15,20-triphenylporphyrin as a Probe of the Transition-State Conformation in Hydrolase-Catalyzed Enantioselective Transesterifications.
J. Org. Chem. 2002, 67, 2144-2151.
Ema, T.; Jittani, M.; Furuie, K.; Utaka, M.; Sakai, T.


High Enantioselectivity and Broad Substrate Specificity of a Carbonyl Reductase: Toward a Versatile Biocatalyst.
J. Org. Chem. 2001, 66, 8682-8684.
Ema, T.; Moriya, H.; Kofukuda, T.; Ishida, T.; Maehara, K.; Utaka, M.; Sakai, T.


Compensation Effect between Differential Activation Enthalpy and Entropy in Subtilisin-Catalyzed Kinetic Resolutions of Secondary Alcohols.
Chem. Lett. 2000, 782-783.
Ema, T.; Yamaguchi, K.; Wakasa, Y.; Tanaka, N.; Utaka, M.; Sakai, T.

Lipase-Catalyzed Transesterification of 2-Hydroxy-2-(pentafluorophenyl) acetonitrile Leading to (1R,2R)- and (1S,2S)-Bis(pentafluorophenyl)-ethane-1,2-diol.
J. Org. Chem. 2000, 65, 2740-2747.
Sakai, T. ; Miki, Y. ; Tsuboi, M. ; Takeuchi, H. ; Ema, T.; Uneyama, K. ; Utaka, M.

加水分解酵素を用いた不斉アルコールの速度論的光学分割: エナンチオ選択性の発現機構
有機合成化学協会誌, 2000, 58, 691-698.
依馬 正, 酒井貴志

バイオサイエンスとインダストリー, 2000, 58, 493-494.
依馬 正


Transition-State Model for Subtilisin-Catalyzed Transesterifications of Secondary Alcohols.
Tetrahedron Lett. 1999, 40, 4367-4370.
Ema, T.; Okada, R.; Fukumoto, M.; Jittani, M.; Ishida, M.; Furuie, K.; Yamaguchi, K.; Sakai, T.; Utaka, M.

(特集・化学のフロンティア'99- はばたけ若き研究者たち-)
化学と工業, 1999, 52, 163-166.
依馬 正


Low-Temperature Method for Enhancement of Enantioselectivity in the Lipase-Catalyzed Kinetic Resolutions of Solketal and Some Chiral Alcohols.
Tetrahedron Lett. 1998, 39, 7881-7884.
Sakai, T.; Kishimoto, T.; Tanaka, Y.; Ema, T.; Utaka, M.

Lipase-Catalyzed Kinetic Resolution of Large Secondary Alcohols Having Tetraphenylporphyrin.
Tetrahedron Lett. 1998, 39, 6311-6314.
Ema, T.; Jittani, M.; Sakai, T.; Utaka, M.

Control of Enantioselectivity in the Baker's Yeast Asymmetric Reduction of g-Chloro b-Diketones to g-Chloro (S)-b-Hydroxy Ketones.
Tetrahedron: Asymmetry 1998, 9, 2681-2692.
Cui, J.-N.; Ema, T.; Sakai, T.; Utaka, M.

Lipase-Catalyzed Kinetic Resolution of 2-Acyloxy-2-(pentafluorophenyl)acetonitrile.
Tetrahedron Lett. 1998, 39, 5233-5236.
Sakai, T.; Miki, Y.; Nakatani, M.; Ema, T.; Uneyama, K.; Utaka, M.

Highly Enantioselective Reduction of Carbonyl Compounds Using a Reductase Purified from Bakers' Yeast.
J. Org. Chem. 1998, 63, 4996-5000.
Ema, T.; Sugiyama, Y.; Fukumoto, M.; Moriya, H.; Cui, J.-N.; Sakai, T.; Utaka, M.

Origin of the Enantioselectivity of Lipases Explained by a Stereo-Sensing Mechanism Operative at the Transition State.
Bull. Chem. Soc. Jpn. 1998, 71, 443-453.
Ema, T.; Kobayashi, J.; Maeno, S.; Sakai, T.; Utaka, M.


Enhancement of the Enantioselectivity in Lipase-Catalyzed Kinetic Resolutions of 2H-Azirine-2-methanol by Lowering the Temperature to -40 C.
J. Org. Chem. 1997, 62, 4906-4907.
Sakai, T.; Kawabata, I.; Kishimoto, T.; Ema, T.; Utaka, M.

Highly Regio- and Enantioselective Reduction of 1-Chloro-2,4-alkanediones Using Bakers' Yeast: Effects of Organic Solvents as Additives.
Tetrahedron Lett. 1997, 38, 3021-3024.
Cui, J.-N.; Teraoka, R.; Ema, T.; Sakai.T.; Utaka, M.

Lipase-Catalyzed Efficient Kinetic Resolution of 3-Hydroxy-3-(pentafluoro-phenyl)propionitrile and Related Compounds.
Tetrahedron Lett. 1997, 38, 1987-1990.
Sakai.T.; Takayama, T.; Ohkawa, T.; Yoshio, O.; Ema, T.; Utaka, M.

New Optically Active Diporphyrin Having a Chiral Cyclophane as a Spacer.
Chem. Lett. 1997, 487-488.
Ema, T.; Misawa, S.; Nemugaki, S.; Sakai, T.; Utaka, M.


Highly Efficient and Convenient Regeneration of NADPH for Asymmetric Reduction Using Bakers' Yeast Cell Free Extract.
Chem. Lett. 1996, 1079-1080.
Utaka, M.; Yano, T.; Ema, T.; Sakai, T.

Kinetic Resolution of Racemic 2-Substituted 3-Cyclopenten-1-ols by Lipase-Catalyzed Transesterifications: A Rational Strategy to Improve Enantioselectivity.
J. Org. Chem. 1996, 61, 8610-8616.
Ema, T.; Maeno, S.; Takaya, Y.; Sakai, T.; Utaka, M.

Significant Effect of Acyl Groups on Enantioselectivity in Lipase-Catalyzed Transesterifications.
Tetrahedron: Asymmetry 1996, 7, 625-628.
Ema, T.; Maeno, S.; Takaya, Y.; Sakai, T.; Utaka, M.


Unusual Picosecond 1(p,p*) Deactivation of Ruffled Nonplanar Porphyrins.
Chem. Phys. Lett. 1995, 245, 441-447.
Gentemann, S.; Medforth, C. J.; Ema, T.; Nelson, N. Y.; Smith, K. M.; Fajer, J.; Holten, D.

Ruffling in a Series of Nickel(II) meso-Tetrasubstituted Porphyrins as a Model for the Conserved Ruffling of the Heme in Cytochromes c.
J. Am. Chem. Soc. 1995, 117, 11085-11097.
Jentzen, W.; Simpson, M. C.; Hobbs, J. D.; Song, X.; Ema, T.; Nelson, N. Y.; Medforth, C. J.; Smith, K. M.; Veyrat, M.; Mazzanti, M.; Ramasseul, R.; Marchon, J.-C.; Takeuchi, T.; Goddard, W. A.; Shelnutt, J. A.

Synthesis and CD Spectrum of Chiral Porphyrin Dimer.
Tetrahedron Lett. 1995, 36, 5905-5908.
Ema, T.; Nemugaki, S; Tsuboi, S.; Utaka, M.

Complexation-induced Catalysis in Zinc Insertion into Cationic Porphyrin.
Chem. Lett. 1995, 941-942.
Mizuani, T.; Koyama H.; Ema, T.; Nomura, A.; Yoshida T.; Ogoshi, H.

Molecular Recognition: New Chiral Metalloporphyrins as Receptor Models.
Supramol. Chem. 1995, 6, 115-124.
Ogoshi, H.; Ema, T.; Kato, Y.; Mizutani, T.; Kuroda, Y.

Crystal Structure of a Remarkably Ruffled Nonplanar Porphyrin (Pyridine)[5,10,15,20-Tetra(tert-butyl)porphyrinato]zinc(II).
J. Chem. Soc., Chem. Commun. 1995, 733-734.
Senge, M. O.; Ema, T.; Smith, K. M.

Restricted Internal Rotation of Amino Acid Esters. Quantitative Evaluation of Rigidity of a Molecule in terms of Internal Rotational Entropy.
Tetrahedron 1995, 51, 473-484.
Mizutani, T.; Ema, T.; Ogoshi, H.


5,10,15,20-Tetra-tert-butylporphyrin and Its Remarkable Reactivity in the 5- and 15-Positions.
Angew. Chem., Int. Ed. Engl. 1994, 33, 1879-1881.
Ema, T.; Senge, M. O.; Nelson, N. Y.; Ogoshi, H.; Smith, K. M.

Design and Synthesis of a Trifunctional Chiral Porphyrin with C2 Symmetry as a Chiral Recognition Host for Amino Acid Esters.
J. Am. Chem. Soc. 1994, 116, 4240-4250.
Mizutani, T.; Ema, T.; Tomita, T.; Kuroda, Y.; Ogoshi, H.

Mechanism of Induced Circular Dichroism of Amino Acid Ester-Porphyrin Supramolecular Systems. Implications to the Origin of the Circular Dichroism of Hemoprotein.
Inorg. Chem. 1994, 33, 3558-3566.
Mizutani, T.; Ema, T.; Yoshida, T.; Renne, T.; Ogoshi, H.

油化学, 1994, 43, 769-778.
生越久靖, 依馬 正, 水谷 義


Recognition of a-Amino Acid Esters by Zinc Porphyrin Derivatives via Coordination and Hydrogen Bonding Interactions. Evidence for Two-Point Fixation from Thermodynamic and Induced Circular Dichroism Spectroscopic Studies.
Inorg. Chem. 1993, 32, 2072-2077.
Mizutani, T.; Ema, T.; Yoshida, T.; Kuroda, Y.; Ogoshi, H.

Recognition of Chirality and Residual Groups of Amino Acid Esters using New Trifunctional Chiral Porphyrins with C2 Symmetry.
J. Chem. Soc., Chem. Commun. 1993, 520-522.
Mizutani, T.; Ema, T.; Tomita, T.; Kuroda, Y.; Ogoshi, H.


Synthesis and Photoreaction of 1,2,3,4-Tetra-t-butylnaphthalene: A Highly Crowded Naphthalene Derivative and Its Valenceisomers.
Tetrahedron Lett. 1992, 33, 1619-1620.
Miki, S.; Ema, T.; Shimizu, R.; Nakatsuji, H.; Yoshida, Z.


Selective Syntheses of Unsymmetrical meso-Arylporphyrins.
Tetrahedron Lett. 1991, 32, 4529-4532.
Ema, T.; Kuroda, Y.; Ogoshi, H.